December 28, 2007, 7:34 AM CT
Handling pesticides associated with asthma

New research on farm women has shown that contact with some usually used pesticides in farm work may increase their risk of allergic asthma.
Farm women are an understudied occupational group, said Jane Hoppin, Sc.D., of the National Institute of Environmental Health Sciences and lead author of the study. More than half the women in our study applied pesticides, but there is very little known about the risks.
The study was reported in the first issue for January of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.
The scientists assessed pesticide and other occupational exposures as risk factors for adult-onset asthma in more than 25,000 farmwomen in North Carolina and Iowa. They used self-reports of doctor-diagnosed adult asthma, and divided the women into groups of allergic (atopic) or non-allergic (non-atopic) asthma based on a history of eczema and/or hay fever.
They found an average increase of 50 percent in the prevalence of allergic asthma in all farm women who applied or mixed pesticides. Remarkably, eventhough the association with pesticides was higher among women who grew up on farms, these women still had a lower overall risk of having allergic asthma in comparison to than those who did not grow up on farms, due to a protective effect that remains poorly understood.........
Posted by: Scott Read more Source
November 29, 2007, 10:19 PM CT
Quit Rates Double With Counseling And Free Nicotine Patches
Increasing the level of Quitline smoking cessation services and offering free nicotine patches are a successful and cost-effective way to reduce smoking rates, as per two new studies in the recent issue of Tobacco Control, a peer-evaluated publication of the British Medical Journal. Both studies were conducted by scientists at Kaiser Permanentes Center for Health Research in Portland, the Oregon Health Department, and Free & Clear in Seattle, a phone-based tobacco therapy program.
One study observed that the number of callers to the Oregon Tobacco Quitline jumped from 6,426 to 13,646 annually, and their quit rates nearly doubled, when Oregon became the first state in the country to promote Quitline services by combining one 30-minute telephone counseling session with a free two-week supply of Nicotine Replacement Therapy using earned or unpaid media to increase calls from smokers.
Previous to this initiative, the Oregon Tobacco Quitline provided one 30-minute telephone counseling session with no NRT and promoted the service through paid advertising. Analysis of the one-year results showed that the free NRT initiative was extremely successful even though its total costs were higher than the costs of the pre-initiative program ($2.25 million versus $1.97 million) because:.........
Posted by: Scott Read more Source
December 12, 2006, 5:04 AM CT
Almost Half Of Lung Cancer Patients Go Back To Cigarettes
New research has shown that the development of lung cancer and surgery to remove it is not yet enough to put a number of smokers off picking up cigarettes again.
A Washington University School of Medicine study of 154 smokers who had surgery to remove early stage lung cancer found almost half picked up a cigarette again within 12 months of their operations.
The scientists observed that 43 per cent of patients smoked at some point after surgery and 37 per cent were smoking 12 months after their operation.
Furthermore, 60 per cent of those who took up smoking again did so within two months of surgery.
Highlighting the dangerous addictiveness of cigarettes, Mark Walker, a clinical psychology expert and assistant professor of medicine at Washington University, said: "These patients are all addicted, so you cannot assume they will easily change their behaviour simply because they have dodged this particular bullet.
"Their choices are driven by insidious cravings for nicotine".
Contrary to predictions, scientists found no link between the quantity of smoking and the ability to quit, and also discovered that higher education was linked to a greater likelihood of smoking after surgery.
"It wasn't the number of cigarettes smoked daily that determined who couldn't quit, but how long they continued to smoke before surgery," Professor Walker explained.........
Posted by: Scott Permalink Source
November 2, 2006, 5:29 PM CT
Smoking Related Cancers
There are currently about fifty million smokers in the U.S. and there are another fifty million ex-smokers. Cigarette smoking has been linked to several human malignancies. Some of these links like the relationship between smoking and lung cancer are well established. In some other cases the relationship between smoking and cancer is not very well established. However several studies have clearly shown the malignant potential of chemical substances in cigarette smoke. This article is an attempt to summarize some of the known links between cigarette smoking and caner.
Lung cancerLung cancer has a strong association with smoking. On average, smokers increase their risk of lung cancer between 5 and 10-fold compared to never smokers. Even though lung cancer can occur in non-smokers, it should be appreciated that more than 90 percent of all lung cancer patients are current or past smokers. Some sub types of lung cancer like small cell lung cancer is more strongly associated with smoking than others. There is plenty of research evidence in the literature linking lung cancer to smoking. A recent study published in the British Journal Of Medicine (Ref: BMJ 1997) concluded that the accumulated evidence support the fact secondhand exposure to cigarette smoke could lead to lung cancer. ........
Posted by: Agarwaal MD Permalink
October 1, 2006, 7:38 PM CT
Predicting drug sensitivity in lung cancer
What if we can clearly predict which of those patients with non-small cell lung cancer would respond to a cisplatin-based chemotherapy. This would benefit a number of patients with non-small cell lung cancer, since oncologists could use another drug combination to treat these patients. This is what scientists from MD Anderson Cancer Center is trying to achieve.
Non-small cell lung cancer cells with a defective version of a potential tumor suppressor gene are highly resistant to attack by a platinum-based drug usually used to treat the disease, scientists at The University of Texas M. D. Anderson Cancer Center and The University of Texas Southwestern Medical Center at Dallas report in the cover article of the latest issue of Cancer Research.
The gene may provide a potential biomarker for selecting among chemotherapy choices for non-small-cell lung cancer as well as a therapeutic target for restoring the drug cisplatin's punch in treating resistant forms of the disease, says senior author Lin Ji, Ph.D., associate professor in M. D. Anderson's Department of Thoracic and Cardiovascular Surgery.
Scientists at the two institutions, working under a joint National Cancer Institute Specialized Program of Research Excellence (SPORE) in Lung Cancer grant, have identified three tumor-suppressor genes on chromosome 3. The latest paper refines the impact of one of those genes, NPRL2, on the most common form of lung cancer.........
Posted by: Scott Permalink Source
June 19, 2006, 9:23 PM CT
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Posted by: Janet Permalink
June 10, 2006, 6:09 PM CT
Vaccine Against Nicotine Addiction
UCSF's Habit Abatement Clinic is testing a vaccine that enlists help from the immune system to keep nicotine away from the brain. The vaccine is designed to help smokers quit and to limit the urge to start smoking again.
Called NicVax, the investigational vaccine is being developed by Nabi Biopharmaceuticals to prevent and treat nicotine addiction and to help people quit smoking. Normally when a smoker inhales, nicotine is carried by the bloodstream to the brain, where it triggers neuro-receptors to generate positive sensations that can lead to addiction. The vaccine stimulates the immune system to produce antibodies that recognize the small nicotine molecule. Bound to these antibodies, nicotine molecules no longer can cross the blood-brain barrier and enter the brain.
"With little or no nicotine reaching the brain, smoking is less rewarding. That gives the smoker a chance to change the behavioral and social factors that also influence smoking," said Victor Reus, MD, principal investigator for the study at UCSF.
Because immune antibodies remain in the body for some time, Reus said it is hoped that the vaccine also will prevent relapse. When a vaccinated smoker lights up months after quitting, the person should not experience the nicotine-triggered reward that tempts most people back into the habit.........
Posted by: Janet Permalink Source
April 4, 2006, 8:39 PM CT
People With Allergies Are Less Likely To Develop Brain Tumors
In their quest to determine whether immune system surveillance guards against brain tumor development, scientists at The University of Texas M. D. Anderson Cancer Center have found that allergies and asthma that stimulate inflammation may be protective, but use of antihistamines to control the inflammation could eliminate that protection.
In this study, reported at the annual meeting of the American Association for Cancer Research (AACR), the scientists also associated chicken pox infection with a significantly reduced risk of developing brain tumors.
The scientists say the findings suggest that a small amount of inflammation in the brain may rev up the immune system enough to protect against brain tumor development. But they stress that no one should give up antihistamines or shun use of a chicken pox vaccine because of this study.
"Brain tumors are exceedingly rare, and a number of, a number of people use antihistamines, so we certainly are not suggesting a direct correlation between the two, or between chicken pox and tumors," says the study's lead author, Melissa Bondy, Ph.D., a professor in the Department of Epidemiology. "What this study may do is help us begin to understand if the immune system plays a role in development of different kinds of brain tumors".........
Posted by: JoAnn Permalink Source
March 30, 2006, 4:37 PM CT
Sleep Apnea Treatment And The Heart
Patients with obstructive sleep apnea have enlarged and thickened hearts that pump less effectively, but the heart abnormalities improve with use of a device that helps patients breathe better during sleep, as per a new study in the April 4, 2006, issue of the Journal of the American College of Cardiology.
"Not only are the shape and size of the heart affected, the right side of the heart was dilated and the heart muscle on the left side was thicker in patients with obstructive sleep apnea, but the pump function was also reduced. The changes were directly correlation to the severity of the problem. Treating the problem brought significant improvements in the affected parameters, as well as in symptoms, in a relatively short period of time of six months," said Bharati Shivalkar, M.D., Ph.D. from the University Hospital Antwerp in Antwerp, Belgium.
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder associated with increased risk of cardiovascular disease. Typically the osa syndrome is characterized by repeated partial or complete closure of the pharynx, gasping episodes, sleep fragmentation, and daytime sleepiness. Prior studies have shown that sleep apnea is associated with hypertension and other cardiovascular risks, including stroke, ischemia, arrhythmias, or sudden death.........
Posted by: Scott Permalink Source
March 24, 2006, 0:17 AM CT
Why Older People Quit Smoking?
Research reported in the Journal of the American Geriatrics Society found that elderly women are more likely to quit smoking than elderly men, while results are just the opposite for studies among younger populations.
"Smoking cessation was also observed more frequently among elders who had recently been diagnosed with cancer. In addition, the rate of recidivism (resuming smoking) was only 16 percent among the elderly smokers who quit, whereas prior studies report relapse rates of 35-45 percent, says head researcher Dr. Heather E. Whitson of Duke University Center for Aging." These findings indicate that older smokers may quit smoking for different reasons than younger smokers.
The study did not directly assess the smokers' reasons for quitting, but the authors postulate that factors such as lack of transportation, poor financial situation and dementia might contribute to smoking cessation in older smokers. Regardless of reason, the cessation of smoking may lower the risk of death, even when it occurs at an advanced age. The seven-year death rate among non-quitters in the study was 51.6% compared to only 44% among the quitters (eventhough the difference was not statistically significant).
The Association for the Advancement of Retired Persons (AARP) conducted a survey of its members to find that only 39 percent of smokers had been advised by their physicians in the past year to stop smoking. Physicians may assume that older smokers are unlikely to give up one their few remaining pleasures. However, the Duke data suggests that further research is needed to understand the unique motivations and potential benefits of smoking cessation in the elderly.........
Posted by: Janet Permalink Source
March 15, 2006, 6:58 AM CT
New way to quit smoking
Smokers trying to kick the habit might stand a better chance of staying smoke-free if they begin using replacement nicotine patches or gum in the weeks before they quit cigarettes.
That's a theory a team led by the Clinical Trials Research Unit (CTRU) at The University of Auckland's School of Population Health is testing in a study funded by the Health Research Council and National Heart Foundation.
Principal investigator Dr Chris Bullen says the conventional wisdom is that people trying to quit throw away their cigarettes and immediately replace them with a nicotine substitute, such as nicotine patches or chewing gum.
But some recent small-scale studies have suggested that the earlier use of a nicotine substitute might improve the chances of a person staying smokefree.
"It's been suggested that if a smoker starts using nicotine substitutes about a fortnight before quitting cigarettes, they are significantly more likely to remain smokefree six months later.
"We want to test this idea in a properly controlled, randomised trial".
Scientists from The University of Auckland together with colleagues in The Quit Group and the University of Otago will work with 1100 people, enlisted through the national Quitline. Half the participants will be offered nicotine patches or gum two weeks before they attempt to quit; the other half will begin using the patches or gum on the day that they quit.........
Posted by: Janet Permalink Source
March 15, 2006, 6:28 AM CT
Reducing Fine Particulate Air Pollution May Save Lives
Investigators who extended the Harvard Six Cities fine particulate air pollution study by eight years found that reduced levels of tiny particle pollution during this period lowered mortality risk for participants.
The results appear in the second issue for March 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.
The findings of the original Harvard Six Cities study (1979 to 1990) revealed an association between levels of fine particulate matter pollution and mortality risk. The new study, which was conducted from 1990 to 1998, reports on this later period of reduced air pollution concentration.
Francine Laden, Sc.D., of Channing Laboratory in Boston, Massachusetts, and three associates found that the largest drops in adjusted mortality rates were in cities with the greatest reduction in fine particulate air pollution (PM2.5). The investigators' findings remained valid even after setting controls for the general increase in adult life expectancy that occurred in the U.S. during both study periods (1979 to 1989 and 1990 to 1998).
"This reduction was observed specifically for deaths due to cardiovascular and respiratory disease and not from lung cancer, a disease with a longer latency period and less reversibility," said Dr. Laden.........
Posted by: Scott Permalink Source
March 14, 2006, 7:25 AM CT
Radon And Lung Cancer
Scientists and researchers point out that recently there is an increase in the number of lung cancer diagnosis among nonsmokers. This is particularly true for women. Recent sad and untimely demise of Dana Reeve has heightened public awareness about lung cancer, particularly among people who have never smoked.
While cigarette smoking is still the leading cause of lung cancer, other factors such as passive smoking and exposure to radon gas from the house environment are increasingly coming in to highlight. Lung cancer from smoking and passing exposure to smoke claims an estimated 163,000 lung cancer deaths in the U.S. every year. It is estimated that radon is the cause of another 21,000 cases of lung cancer deaths annually in the United States, according to the U.S. Environmental Protection Agency estimates.
Experts claim that a number of of these deaths due to exposure to radon gas could be prevented if enough precautions are taken. Nationally, about 1 in 15 homes has high radon levels, and that number is higher in some states.
It is not possible to detect the presence of radon gas in your house environment because it is a colorless, odorless tasteless gas. Radon gas is produced as part of the natural decay process of uranium. Areas, which have high content of mineral such as some mountainous areas, may have a higher risk of increased levels of radon gas.........
Posted by: Scott Permalink
March 7, 2006, 6:54 PM CT
A tribute to Dana Reeves
When Dana Reeves announced the news of her lung cancer in August nobody expected that she would go away so quickly. The singer-actress Dana Reeves married the super star of the "Superman" movies and soon found herself to be devoted his care and his cause after he was paralyzed. Less than a year after her husband's death she was diagnosed with lung cancer and she died, a year-and-a-half after her husband because of this disease. She was 44 years old.
On 12th of January she belted out Carole King's "Now and Forever" at a packed Madison Square Garden during a ceremony honoring hockey star Mark Messier, a friend. She looked quite healthy at that time and this sad demise was sudden and unexpected.
It is not surprising for a number of of us who have seen the realities of patients who are suffering from this awful disease.
Dana Reeve, who lived in Pound Ridge, died Monday night at Memorial Sloan-Kettering Medical Center in Manhattan, said the Christopher Reeve Foundation president Kathy Lewis.
Officials would not discuss Reeve's therapy or say when she entered the hospital. But Lewis said she visited her there on Friday, when Reeve was "tired but with her typical sense of humor and smile, always trying to make other people feel good, her characteristic personality".........
Posted by: Scott Permalink
February 22, 2006, 10:57 PM CT
Obesity and asthma medications
Marc Peters-Golden, M.D
As the nation's collective waistline has swelled in recent decades, rates of asthma diagnoses also have accelerated. Indeed, much research has affirmed a link between the two conditions.
But doctors also recognize that asthma may not behave the same way among people who have different body types. With a variety of asthma medications on the market, what kinds work best for lean people and what kinds work best for obese people? The answer may be different for each group.
A new study suggests that people who are overweight or obese may have better results with the prescription pill sold as Singulair than with a type of inhaled steroid, while leaner people may have better luck with an inhaled steroid, called beclomethasone and sold as beclovent, vanceril and other brand names. The findings are reported in the new issue of the European Respiratory Journal.
"It is increasingly recognized that obese people are more prone to develop asthma, but there is no information about whether obesity influences people's responses to particular asthma medications," says lead author Marc Peters-Golden, M.D., professor of internal medicine and director of the Fellowship Program in Pulmonary and Critical Care Medicine at the University of Michigan Medical School.
"Our findings are the first to suggest the possibility that obesity might be a factor that influences how well asthmatics respond to particular medications," Peters-Golden says.........
Posted by: JoAnn Permalink Source
January 28, 2006, 5:01 PM CT
Thermal Energy Procedure For Asthma
Up until now, if you suffer from asthma, medicine has been the only therapy available to you for relief. But now, clinical scientists at the Hospital of the University of Pennsylvania (HUP) hope to open up a new avenue to alleviate the debilitating symptoms of asthma - through an investigative bronchoscopic procedure where the smooth muscle of the airway, which causes the spasm, is reduced using thermal energy.
"Even though the smooth muscle in your airway serves no identifiable purpose, when something does go wrong with it, it can cause problems," explains Ali Musani, MD, an interventional pulmonologist at Penn and principal investigator of the study. "It can constrict, tighten, and narrow the airway considerably -- causing real health consequences for asthmatics".
Interventional pulmonologists will explore, for the first time in the United States, a new way to treat asthma. Physicians will actually go into the airways with a bronchoscope, which is a routine procedure, and by generating and applying thermal energy, will reduce areas of underlying smooth muscle in the small to medium size airways with a new medical device. The Alairandreg; System - which is manufactured by Asthmatx, Inc. - consists of a single-use device and a controller that delivers thermal energy to the bronchial wall during an outpatient bronchoscopic procedure known as Bronchial Thermoplasty™.........
Posted by: JoAnn Permalink
January 11, 2006, 8:13 PM CT
Resistant Bacteria In Intensive Care Units
A dangerous drug-resistant bacterium is becoming more prevalent in a number of intensive care units, according to an article in the Feb. 1 issue of Clinical Infectious Diseases, now available online.
Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for a variety of infections that patients often acquire in the hospital. Skin infections are the most common, but MRSA can also infect the heart, the lungs, and the digestive tract. The emergence of MRSA and other drug-resistant bacteria may be due in part to over-prescribing and overuse of antibiotics.
Scientists at the Centers for Disease Control and Prevention examined MRSA data from more than 1,200 intensive care units (ICUs) from 1992 to 2003. They found that in 1992, 36 percent of S. aureus isolates were drug-resistant; but in 2003, 64 percent of isolates were MRSA, an increase of about 3 percentage points per year.
Despite the increase in MRSA prevalence, there was also a decrease in MRSA that was resistant to multiple drugs. The scientists hypothesize that the influx of MRSA strains from the community might have replaced those multidrug-resistant strains associated with the hospital.
"Unlike traditional MRSA the community strain is very fit - it causes infection in healthy people," said CDC epidemiologist Dr. Monina Klevens. "When it is introduced into a hospital, where ill patients are more vulnerable to infection, it has the potential to cause significant morbidity and mortality".........
Posted by: Mark Permalink
January 11, 2006, 7:42 PM CT
Reducing Secondhand Smoke in Homes
People who see news stories and advertisements about the dangers of secondhand smoke are more likely to feel that it is harmful, and may restrict smoking at home, according to new research published in the American Journal of Health Behavior.
The study by W. Douglas Evans, of the nonprofit research corporation RTI International, and his colleagues found that anti-secondhand smoke media messages have a strong indirect effect on smoking restrictions in the home.
Anti-secondhand smoke media account for 10 percent of people's negative attitudes about secondhand smoke, but these negative attitudes explain nearly 60 percent of home smoking restrictions, Evans said.
"Media work through changing people's attitudes to get them to change home smoking rules," he said.
People may "have to process the information" they get from the media through family discussions or through one person in a household taking a strong position on secondhand smoke before the change in attitude becomes a change in home restrictions, Evans suggested.
According to 2003 statistics compiled by the Centers for Disease Control and Prevention, secondhand smoke exposure is the third leading cause of preventable death in the United States. Secondhand smoke exposure has been linked to lung cancer and heart disease in adults and severe respiratory infections and asthma, especially in infants and young children.........
Posted by: Janet Permalink
January 9, 2006, 10:08 PM CT
Why Blacks have lower lung cancer surgery rates?
Christopher Lathan, MD
Even when they have equal access to specialized care, blacks with potentially curable lung cancer are about half as likely as whites to undergo surgery that could save their lives, as per a studyby Dana-Farber Cancer Institute researchers.
Designed to identify the causes of racial discrepancies in lung cancer therapy in the United States, the research ruled out unequal access to medical care as the sole explanation. It did show that blacks were somewhat less likely to be offered lung cancer surgery, and were slightly more likely to refuse it than were whites. Overall, the study found that blacks who had equal access to care were 45 percent less likely than whites to have lung cancer surgery.
These findings point to a subtle and complex "communications problem" underlying the inequality, said Christopher Lathan, MD, of Dana-Farber and lead author of the report that is published online by the Journal of Clinical Oncology and will be in the journal's Jan. 20 print issue. "Something's not happening. There was no specific reason that could be found, but there needs to be more attention paid to the doctor-patient interaction."
The generally poorer health of blacks and other racial minorities is often blamed on social and financial obstacles to obtaining medical care. The new study, however, documents that the lower rate of surgery for black lung cancer patients "is not just about access to care or not being physically able to undergo therapy," said Craig Earle, MD, of Dana-Farber and the paper's senior author. "There still seems to be a racial disparity."........
Posted by: Scott Permalink
January 4, 2006Telephone counseling for smokers
People seeking help to quit smoking have a number of options, from support groups to nicotine replacement to prescription drugs designed to lessen the urge to light up. Now Washington University scientists and BJC HealthCare are testing another one: telephone counseling.
The Call-2-Quit project, funded by a three-year, $1.35 million grant from the Centers for Disease Control and Prevention, will compare two approaches to smoking cessation telephone counseling. Both interventions include discussion of key tasks for quitting smoking, but they differ in counseling style and in the range of topics that are covered.
Over the course of several weeks, those who call for phone counseling will participate in seven sessions with trained smoking cessation counselors to learn about methods that may help them stay away from cigarettes.
"We want to provide state-of-the-art counseling," says psychology expert Mark S. Walker, Ph.D., instructor of medicine in Washington University's Division of Health Behavior Research and the study's principal investigator. "The program will vary from person to person, but all callers will receive information about key topics, including avoiding temptation, use of nicotine replacement treatment and overcoming barriers to quitting."
The study will involve employees of BJC HealthCare who are participating in an initiative called Help for Your Health, which was launched two years ago to improve the health of BJC's 26,000 employees.
"BJC HealthCare is committed to helping our employees take charge of their health. Decreasing the incidence of smoking is one of the fastest ways to improving health," according to Steven Lipstein, President and CEO of BJC HealthCare. "Participation in the Call-2-Quit study is one of several initiatives where BJC is taking an active role to address the deadly habit of tobacco use."........
JoAnn Permalink
December 25, 2005, 10:32 AM CTMerry Christmas To All Our Readers
Medicineworld wishes all our readers merry Christmas.
Oh, jingle bells, jingle bells
Jingle all the way
Oh, what fun it is to ride
In a one horse open sleigh
Jingle bells, jingle bells
Jingle all the way
Oh, what fun it is to ride
In a one horse open sleigh........
Daniel Permalink