MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

Medicineworld.org: Archives of health news blog


Go Back to the main health news blog

Subscribe To Health Blog RSS Feed  RSS content feed What is RSS feed?

Archives Of Health News Blog From Medicineworld.Org


May 14, 2009, 5:19 AM CT

Novel therapy for cancer?

Novel therapy for cancer?
A ground-breaking Canada-wide clinical trial led by Dr. Katherine Borden, at the Institute for Research in Immunology and Cancer (IRIC) of the Universit de Montral, has shown that a common anti-viral drug, ribavirin, can be beneficial in the treatment of cancer patients. Published in the journal Blood (First Edition), the study demonstrates that ribavirin suppresses the activities of the eIF4E gene in patients. This gene is dysregulated in 30 percent of cancers including breast, prostate, head and neck, colon and stomach cancer.

The study, inspired by the exciting discoveries made by Dr. Borden at IRIC, was a joint project between her research group, who monitored molecular events in trial patients, and Dr. Sarit Assouline of the Segal Cancer Centre, Jewish General Hospital, who led the clinical part of the trial.

The integration of these two teams made it possible to rapidly move from a research lab to patient tests. The study team targeted the gene by giving trial participants a mimic of its natural target, ribavirin. "Our results are the first to show that targeting eIF4E in humans is clinically beneficial," explains Dr. Borden. "We also found that ribavirin not only blocks eIF4E, it has no side effect on patients".

The trial studied patients with M4/M5 acute myeloid leukemia who had undergone several other treatments that had previously failed. "We had striking clinical improvements with even partial and complete remissions," indicated Assouline.........

Posted by: Janet      Read more         Source


May 13, 2009, 5:29 AM CT

Taking folic acid for a year before pregnancy

Taking folic acid for a year before pregnancy
Women who take folic acid supplements for at least one year before they become pregnant may cut their risk of having a premature baby by half, as per research published this week in the online journal, PLoS Medicine

The study links pre-conceptional folate supplementation of at least one year to reduced early premature delivery rates of 50 to 70 percent, regardless of age, race or other factors. Of particular note is the drop in very early premature births, those babies who are at the greatest risk of complications such as cerebral palsy, mental retardation, chronic lung disease, and blindness.

The study is an observational analysis based on the self-reporting of folate supplementation by 38,033 participants in an earlier trial sponsored by the National Institutes of Health (NIH.) The current study only examined singleton pregnancies and excluded pregnancies with medical or obstetrical complications such as preeclampsia, chronic hypertension, or other abnormalities.

"Through the NIH trials, we received highly accurate evidence of gestational age enabling us to determine that folate supplementation for at least one year is associated with a 70 percent decrease in very early preterm deliveries (20 to 28 weeks gestation) and up to a 50 percent reduction in early preterm deliveries of 28 to 32 weeks," said Radek Bukowski, M.D., Ph.D., associate professor, in the Department of Obstetrics and Gynecology, at the University of Texas Medical Branch at Galveston, the lead study author.........

Posted by: Emily      Read more         Source


May 13, 2009, 5:19 AM CT

Gene In Breast Cancer Pathway

Gene In Breast Cancer Pathway
Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered how a gene crucial in triggering the spread of breast cancer is turned on and off. The findings could help predict whether breast tumors will metastasize and also reveal potential drug targets for preventing metastasis. The study will appear in the May 20th online edition of the Journal of Cell Science.

A few years ago, Einstein researchers discovered a gene called ZBP1 (zipcode binding protein 1), which helps cells to move, grow and organize spatially. "ZBP1 is very active in the developing embryo but largely silent in adult tissues," says Robert H. Singer, Ph.D., professor and co-chair of anatomy and structural biology and co-director of the Gruss-Lipper Biophotonics Center at Einstein. He is one of ZBP1's discoverers and leader of the current study.

Scientists have subsequently observed that ZBP1 is reactivated in several types of cancer, including breast, colorectal, and non-small cell lung cancers; but the gene is silenced in metastasizing cancer cells, as was shown by Dr. Singer and another Einstein scientist, John Condeelis, Ph.D., who also is co-chair of anatomy and structural biology and co-director of the Gruss-Lipper Biophotonics Center at Einstein. The purpose of the current study was to find how the ZBP1 gene is activated and silenced and how it influences the spread of breast cancer.........

Posted by: Janet      Read more         Source


May 13, 2009, 5:17 AM CT

Adults aren't active enough

Adults aren't active enough
A newly released study has sounded the alarm that the majority of Canadian adults are inactive over their lifespan and don't exercise enough during their leisure time. Reported in the International Journal of Behavioral Nutrition and Physical Activity, the study is unique in that it collected information over two decades from the 1981 Canada Fitness Survey, the 1988 Campbell's Survey of Well-Being and from the 2002/4 Physical Activity Longitudinal Study of the Canadian Fitness and Lifestyle Research Institute.

The research team studied a healthy subgroup of Canadians and found almost 56 percent were consistently inactive and only 12 percent of participants remained active with each subsequent survey. The investigation was a partnership between the Universit de Montral, the Sainte-Justine Hospital Research Center, the Centre Hospitalier de l'Universit de Montral, the Canadian Fitness and Lifestyle Research Institute and the Pennington Biomedical Research Center.

"Women and older participants, in comparison to men or their younger peers, were less likely to follow a consistently active lifestyle. And participants with less education and lower household income were also less likely to be active," says main author Tracie A. Barnett, a professor at the Universit de Montral's Department of Social and Preventive Medicine and a researcher at the Sainte-Justine University Hospital Research Center.........

Posted by: JoAnn      Read more         Source


May 13, 2009, 5:14 AM CT

How to build a bigger brain

How to build a bigger brain
Push-ups, crunches, gyms, personal trainers people have a number of strategies for building bigger muscles and stronger bones. But what can one do to build a bigger brain? .

Meditate.

That's the finding from a group of scientists at UCLA who used high-resolution magnetic resonance imaging (MRI) to scan the brains of people who meditate. As per a research findings reported in the journal NeuroImage and currently available online (by subscription), the scientists report that certain regions in the brains of long-term meditators were larger than in a similar control group.

Specifically, meditators showed significantly larger volumes of the hippocampus and areas within the orbito-frontal cortex, the thalamus and the inferior temporal gyrus all regions known for regulating emotions.

"We know that people who consistently meditate have a singular ability to cultivate positive emotions, retain emotional stability and engage in mindful behavior," said Eileen Luders, main author and a postdoctoral research fellow at the UCLA Laboratory of Neuro Imaging. "The observed differences in brain anatomy might give us a clue why meditators have these exceptional abilities." .

Research has confirmed the beneficial aspects of meditation. In addition to having better focus and control over their emotions, a number of people who meditate regularly have reduced levels of stress and bolstered immune systems. But less is known about the link between meditation and brain structure.........

Posted by: Daniel      Read more         Source


May 13, 2009, 5:06 AM CT

Better vaccines

Better vaccines
A team of Princeton University researchers may have found a better way to make a vaccine against the flu virus.

Though theoretical, the work points to the critical importance of what has been a poorly appreciated aspect of the interaction between a virus and those naturally produced defensive proteins called antibodies that fight infection. By manipulating this multi-stage interactive process -- known as antibody interference -- to advantage, the researchers believe it appears to be possible to design more powerful vaccines than exist today.

The findings are described in the May 11 online edition of the Proceedings of the National Academy of Sciences.

"We have proposed that antibody interference plays a major role in determining the effectiveness of the antibody response to a viral infection," said Ned Wingreen, a professor of molecular biology and a member of the Lewis-Sigler Institute for Integrative Genomics. "And we think that in order to get a more powerful vaccine, people are going to want one that minimizes this interference".

Other authors on the paper include Simon Levin, the George M. Moffett Professor of Biology, and Wilfred Ndifon, a graduate student in Levin's lab and first author on the paper.

When a virus like influenza attacks a human, the body mounts a defense, producing antibodies custom-designed to attach themselves to the virus, blocking it from action and effectively neutralizing its harmful effects on the body.........

Posted by: Mark      Read more         Source


May 11, 2009, 9:36 PM CT

Older people need more sun

Older people need more sun
Spending more time in the sunshine could help older people to reduce their risk of developing heart disease and diabetes.

Exposure to sunlight stimulates vitamin D in the skin and older people are more likely to have a vitamin D deficiency due to the natural aging process and lifestyle changes.

Scientists at the University of Warwick have shown vitamin D deficiency is significantly linked to metabolic syndrome, a combination of medical and metabolic disorders that increase the risk of developing cardiovascular disease and diabetes.

The research team, led by Dr Oscar Franco at Warwick Medical School, investigated the association between vitamin D levels in the blood and the prevalence of metabolic syndrome in 3,262 people aged 50-70 years old in China.

His team found a high connection between low vitamin D levels and the prevalence of metabolic syndrome. They found 94% of people in the study had a vitamin D (25-hydroxyvitamin D) deficiency or insufficiency. The results showed 42.3% of these people also had metabolic syndrome.

The results of the study, published in Diabetes Care journal, are consistent with the findings of other studies in Western populations and Dr Franco suggests vitamin D deficiency could become a global health problem.........

Posted by: Janet      Read more         Source


May 11, 2009, 9:31 PM CT

How high glucose damages blood vessels

How high glucose damages blood vessels
New evidence of how the elevated glucose levels that occur in diabetes damage blood vessels may lead to novel strategies for blocking the destruction, Medical College of Georgia scientists say.

They found a decreased ability of blood vessels to relax resulted from increased activity of a natural mechanism for altering protein form and function, says Dr. Rita C.Tostes, physiologist in the MCG School of Medicine.

The scientists suspect increased modification of proteins by a glucose-derived molecule is a player in vascular problems linked to hypertension, stroke and obesity as well.

One aftermath of high glucose levels is low levels of the powerful vasodilator nitric oxide in blood vessels, a shortfall that increases the risk of hypertension and eventual narrowing of the vessels, scientists reported at the American Society of High blood pressure 24th Annual Scientific Program in San Francisco during a joint session with the Council for High Blood Pressure.

"We know diabetes is a major risk factor for cardiovascular disease and we think this is one of the reasons," Dr. Tostes says.

Diabetes increases the risk of cardiovascular disease such as heart disease and stroke, even when glucose, or blood sugar, levels are under control. In fact, about 75 percent of people with diabetes die from some form of heart or blood vessel disease, as per the American Heart Association.........

Posted by: JoAnn      Read more         Source


May 11, 2009, 9:24 PM CT

Genetic cause of of breast cancer

Genetic cause of of breast cancer
The discovery of tumor-suppressor genes has been key to unlocking the molecular and cellular mechanisms leading to uncontrolled cell proliferation the hallmark of cancer. Often, these genes will work in concert with others in a complex biochemical system that keeps our cells growing and dividing, disease free.

Now scientists at the University of North Carolina at Chapel Hill School of Medicine and UNC Lineberger Comprehensive Cancer Center have observed that defects in one gene, called p18, may override the rest, eventually leading to cancer.

This discovery, combined with new laboratory techniques, will help researchers identify and test new therapys for luminal-type tumors, which account for between 70 and 80 percent of all breast cancers, but are generally slower growing than other types.

The results of the research appear in the May 2009 issue of Cancer Cell

Defects in the p18 gene have been observed in different types of human cancer. Senior study author Yue Xiong, Ph.D., William R. Kenan Jr. Distinguished Professor of biochemistry and biophysics, observes, "When this gene is not expressed or is deleted, cells have no braking mechanism. They will continue to grow and divide until they turn into cancer".

Xiong and colleagues specifically targeted the role that p18 plays in the development of luminal breast cancers. Using genetically-engineered mice with deletion of p18 genes, they created a highly reliable model of human breast cancers. The scientists tested their model by analyzing the gene in samples from approximately 300 human patients with breast cancer, proving that the decreased expression of the p18 gene is highly correlated with the development of luminal tumors.........

Posted by: Daniel      Read more         Source


May 11, 2009, 9:22 PM CT

Brain's problem-solving function at work

Brain's problem-solving function at work
A new University of British Columbia study finds that our brains are much more active when we daydream than previously thought.

The study, reported in the Proceedings of the National Academy of Sciences, finds that activity in numerous brain regions increases when our minds wander. It also finds that brain areas linked to complex problem-solving previously thought to go dormant when we daydream are in fact highly active during these episodes.

"Mind wandering is typically linked to negative things like laziness or inattentiveness," says main author, Prof. Kalina Christoff, UBC Dept. of Psychology. "But this study shows our brains are very active when we daydream much more active than when we focus on routine tasks".

For the study, subjects were placed inside an fMRI scanner, where they performed the simple routine task of pushing a button when numbers appear on a screen. The scientists tracked subjects' attentiveness moment-to-moment through brain scans, subjective reports from subjects and by tracking their performance on the task.

The findings suggest that daydreaming which can occupy as much as one third of our waking lives is an important cognitive state where we may unconsciously turn our attention from immediate tasks to sort through important problems in our lives.........

Posted by: Daniel      Read more         Source



Older Blog Entries   1   2   3   4   5   6   7   8   9   10   11   12   13   14   15   16   17   18   19   20   21   22   23   24   25   26   27   28   29   30   31   32   33   34   35   36   37   38   39   40   41   42   43   44   45   46   47   48   49   50   51   52   53   54   55   56   57   58   59   60   61   62   63   64   65   66   67   68   69   70   71   72   73   74   75   76   77   78   79   80   81   82   83   84   85   86   87   88   89   90   91   92   93   94   95   96   97   98   99   100   101   102   103   104   105   106   107   108   109   110   111   112   113   114   115   116   117   118   119   120   121   122   123   124   125   126   127   128   129   130   131   132   133   134   135   136   137   138   139   140   141   142   143   144   145   146   147   148   149   150   151   152   153   154   155   156   157   158   159   160   161   162   163   164   165   166   167   168   169   170   171   172   173   174   175   176   177   178   179   180   181   182   183   184   185   186   187   188   189   190   191   192   193   194   195   196   197   198   199   200   201   202   203   204   205   206   207   208   209   210   211   212   213   214   215   216   217   218   219   220   221   222   223   224   225   226   227   228   229   230   231   232   233   234   235   236   237   238   239   240   241   242   243   244   245   246   247   248   249   250   251   252   253   254   255   256   257   258   259   260   261   262   263   264   265   266   267   268   269   270   271   272   273   274   275   276   277   278   279   280   281   282   283   284   285   286   287   288   289   290   291   292   293   294   295   296   297   298   299   300   301   302   303   304   305   306   307   308   309   310   311   312   313   314   315   316   317   318   319   320   321   322   323   324   325   326   327   328   329   330   331   332   333   334   335   336   337   338   339   340   341   342   343   344   345   346   347   348   349   350   351   352   353   354   355   356   357   358   359   360   361   362   363   364   365   366   367   368   369   370   371   372   373   374   375   376   377   378   379   380   381   382   383   384   385   386   387   388   389   390   391   392   393   394   395   396   397   398   399   400   401   402   403   404   405   406   407   408   409   410   411   412   413   414   415   416   417   418   419   420   421   422   423   424   425   426   427   428   429   430   431   432   433   434   435   436   437   438   439   440   441   442   443   444  

Did you know?
Studies in monkeys and women suggest that unlike traditional estrogen therapy, a diet high in the natural plant estrogens found in soy does not increase the risk of uterine cancer in postmenopausal women, according to Mark Cline, D.V.M., Ph.D., an associate professor of comparative medicine at Wake Forest University Baptist Medical Center.

Medicineworld.org: Archives of health news blog

Acute bacterial meningitis| Alzheimer's disease| Carpal tunnel syndrome| Cerebral aneurysms| Cerebral palsy| Chronic fatigue syndrome| Cluster headache| Dementia| Epilepsy seizure disorders| Febrile seizures| Guillain barre syndrome| Head injury| Hydrocephalus| Neurology| Insomnia| Low backache| Mental retardation| Migraine headaches| Multiple sclerosis| Myasthenia gravis| Neurological manifestations of aids| Parkinsonism parkinson's disease| Personality disorders| Sleep disorders insomnia| Syncope| Trigeminal neuralgia| Vertigo|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.