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March 30, 2006, 7:29 AM CT

Metabolites Responsible For Breast And Prostate Cancer

Metabolites Responsible For Breast And Prostate Cancer
Cancer scientists have discovered that metabolites of natural estrogens can react with deoxyribonucleic acid (DNA) to cause specific damage that initiates the series of events leading to breast, prostate and other human cancers. This understanding of a common mechanism of cancer initiation could result in cancer prevention and in better assessment of cancer risk.

The scientists will present their findings at the 81st annual meeting of the Southwestern and Rocky Mountain Division of the American Association for the Advancement of Science (SWARM-AAAS) on Friday, April 7, at the University of Tulsa, in Tulsa, Okla.

The symposium - "Catechol Estrogen Quinones as Initiators of Breast and other Human Cancers" - will be led by Drs. Ryszard Jankowiak of the Department of Chemistry, Kansas State University, and Ercole Cavalieri of the Eppley Cancer Institute, University of Nebraska Medical Center.

"We have a novel approach to cancer. We know the initiating step," said Dr. Cavalieri. "We think prevention of cancer is a problem we can solve by eliminating this initiating step. Estrogens can induce cancer when natural mechanisms of protection do not work properly in our body, and the estrogen quinones are able to react with DNA. In fact, if these protections are insufficient, due to genetic, lifestyle or environmental influences, then cancer can result.........

Posted by: Janet      Permalink         Source


March 23, 2006, 9:27 PM CT

Eat Salmon To Prevent Prostate Cancer

Eat Salmon To Prevent Prostate Cancer
Everyone knows that eating fish rich in omega-3 fats may protect you from heart attacks. Now there is one more reason to eat fish rich in omega-3 fats. Recent research has shown that fish that contains good amounts of omega-3 fats may actually protect men from prostate cancer.

Omega-3 fatty acids together with omega-6 fatty acids are essential fatty acids that the body cannot synthesize. This has to be supplied from external sources and is shown to protect from heart attacks.

Rich sources of Omega-6 fats include vegetable oils, nuts and seeds. Omega 3 fats are found in oily fish such as salmon and mackerel.

This study led by Dr Mick Brown found while Omega-6 increased the spread of tumor cells into bone marrow, omega-3 blocked the spread.

"We only need about half as much omega-3 as omega-6 - that will still stop cancer cells from spreading," Dr Mick Brown said.........

Posted by: Mark      Permalink


March 15, 2006, 6:25 AM CT

Jalapenos To Fight Prostate Cancer

Jalapenos To Fight Prostate Cancer
Capsaicin, the stuff that turns up the heat in jalapeños, not only causes the tongue to burn, it also drives prostate cancer cells to kill themselves, as per studies reported in the March 15 issue of Cancer Research.

As per a team of scientists from the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, in collaboration with colleagues from UCLA, the pepper component caused human prostate cancer cells to undergo programmed cell death or apoptosis.

Capsaicin induced approximately 80 percent of prostate cancer cells growing in mice to follow the molecular pathways leading to apoptosis. Prostate cancer tumors treated with capsaicin were about one-fifth the size of tumors in non-treated mice.

"Capsaicin had a profound anti-proliferative effect on human prostate cancer cells in culture," said Soren Lehmann, M.D., Ph.D., visiting scientist at the Cedars-Sinai Medical Center and the UCLA School of Medicine. "It also dramatically slowed the development of prostate tumors formed by those human cell lines grown in mouse models."

Lehmann estimated that the dose of pepper extract fed orally to the mice was equivalent to giving 400 milligrams of capsaicin three times a week to a 200 pound man, roughly equivalent to between three and eight fresh habañera peppers - depending on the pepper's capsaicin content. Habañeras are the highest rated pepper for capsaicin content as per the Scoville heat index. Habañero peppers, which are native to the Yucatan, typically contain up to 300,000 Scoville units. The more popular Jalapeño variety from Oaxaca, Mexico, and the southwest United States, contains 2,500 to 5,000 Scoville units.........

Posted by: Mark      Permalink         Source


February 24, 2006, 10:02 PM CT

'Virus Chip' Detects New Virus In Prostate Tumors

'Virus Chip' Detects New Virus In Prostate Tumors
UCSF and Cleveland Clinic scientists have discovered a new virus in human prostate tumors. The type of virus, closely related to viruses typically found in mice, has never been detected in humans. The virus's link to human disease is still unclear, and more study is needed to determine the relationship between the virus and cancer, if any, the scientists say.

The discovery was made with the same DNA-hunting "virus chip" used to confirm the identity of the SARS virus three years ago.

While the genetics of prostate cancer are complex, one of the first genes implicated in the disease was RNASEL, a gene that serves as an important defense against viruses. Given the anti-viral role of this gene, some scientists have speculated that a virus could be involved in some types of prostate cancers in men with mutated RNASEL genes.

In the new study, the researchers discovered the novel virus far more often in human prostate tumors with two copies of the RNASEL gene mutation than in those with at least one normal copy.

"This is a virus that has never been seen in humans before," said Eric Klein, MD, a collaborator in the research and head of urologic oncology at the Glickman Urologic Institute of Cleveland Clinic. "This is consistent with previous epidemiologic and genetic research that has suggested that prostate cancer may result from chronic inflammation, perhaps as a response to infection."........

Posted by: Mark      Permalink         Source


January 18, 2006, 7:46 PM CT

Turmeric And Cauliflower To Halt Prostate Cancer

Turmeric And Cauliflower To Halt Prostate Cancer
Rutgers scientists have found that the curry spice turmeric holds real potential for the therapy and prevention of prostate cancer, especially when combined with certain vegetables.

The researchers tested turmeric, also known as curcumin, along with phenethyl isothiocyanate (PEITC), a naturally occurring substance especially abundant in a group of vegetables that includes watercress, cabbage, winter cress, broccoli, Brussels sprouts, kale, cauliflower, kohlrabi and turnips. "The bottom line is that PEITC and curcumin, alone or in combination, demonstrate significant cancer-preventive qualities in laboratory mice, and the combination of PEITC and curcumin could be effective in treating established prostate cancers," said Ah-Ng Tony Kong, a professor of pharmaceutics at Rutgers, The State University of New Jersey.

The discovery was announced in the Jan. 15 issue of the journal Cancer Research by Kong and colleagues at Rutgers' Ernest Mario School of Pharmacy.

Prostate cancer is the second leading cause of cancer death in men in the United States, with a half-million new cases appearing each year. The incidence and mortality of prostate cancer have not decreased in past decades despite tremendous efforts and resources devoted to therapy. This is because advanced prostate cancer cells are barely responsive even to high concentrations of chemotherapeutic agents or radiotherapy.........

Posted by: Mark      Permalink


January 18, 2006, 0:21 AM CT

Controversy Over Prostate Cancer Screening

Controversy Over Prostate Cancer Screening John Concato, M.D.
A screening test for prostate cancer that measures prostate-specific antigen (PSA) levels does not improve survival, scientists at the Veterans Affairs (VA) Connecticut Healthcare System and Yale School of Medicine report in the January 9 Archives of Internal Medicine.

Prostate cancer is the most common cancer affecting American men and ranks second in mortality. According to the study, screening tests almost always increase the detection of cancer, but among other requirements for improving survival, the tumors detected must be both fatal (if left untreated) yet curable.

PSA, a protein produced in the prostate, is found in the blood of healthy men. Prostate cancer often increases PSA levels in the blood, but a similar increase can be caused by non-malignant enlargement of the prostate gland (prostatism) or prostate infections.

To test the impact of prostate cancer screening on survival, the scientists conducted a case-control review of the medical records of over 1,000 male veterans age 50 or older receiving care at 10 VA medical centers in New England. Half of the men had died with prostate cancer; the other half were living and matched to be the same age as those who died. The study included up to nine years of follow-up after the diagnosis of cancer. The scientists compared the group that died to the group that lived and found that the same fraction of men had received screening with the PSA test.........

Posted by: Mark      Permalink


January 10, 2006, 6:20 PM CT

Obesity And Prostate Cancer

Obesity And Prostate Cancer Harder
Obesity may make it harder to find prostate cancer, leading to delayed diagnosis and putting some men at an even greater risk for dying of the disease, according to a multi-university study led by a researcher from Duke University Medical Center and the Duke Prostate Center. As a result, the scientists are recommending that physicians be particularly thorough when examining obese men for prostate cancer.

The study showed that, up to a point, prostate gland size increases as body mass index (BMI) grows. BMI is a body fatness measurement based on weight adjusted for height. With larger prostate glands seen among obese men, doctors may be 20 percent to 25 percent less likely to identify prostate cancer when it is present, said Stephen Freedland, M.D., principal investigator and Assistant Professor in Duke's Department of Surgery-Urology. Freedland also holds an appointment in Surgery at the Durham VA Medical Center.

"Diagnosing prostate cancer is a bit like finding a needle in a haystack," Freedland said. "The bigger the haystack you have, the harder it is to find the needle, and in this case, we may be missing cancers in obese men".

Scientists published their findings in the February 2006 issue of the Journal of Urology.

Prostate cancer is the second most common type of cancer affecting men in the U.S., and a man has a one in six chance of being diagnosed with prostate cancer at some point during his life, according to the Prostate Cancer Foundation. Obese men diagnosed with the disease are 20 percent to 35 percent more likely to die from it than a man of normal weight. Individuals are characterized as obese if they have a BMI greater than 30. According to the Centers for Disease Control and Prevention, 30 percent of American adults are obese.........

Posted by: Mark      Permalink


December 25, 2005, 10:32 AM CT

Merry Christmas To All Our Readers

Merry Christmas To All Our Readers
Medicineworld wishes all our readers merry Christmas.

Oh, jingle bells, jingle bells

Jingle all the way

Oh, what fun it is to ride

In a one horse open sleigh

Jingle bells, jingle bells

Jingle all the way

Oh, what fun it is to ride

In a one horse open sleigh........

Daniel      Permalink


December 15, 2005

New Model Of Prostate Cancer

New Model Of Prostate Cancer Thomas J. Rosol
Scientists have developed a new line of prostate cancer cells that they hope will provide a better model to study the disease.

This new cancer-cell line has already provided some help. One new study in mice identified a promising possible treatment to reduce skeletal pain that accompanies prostate cancer. Researchers found that a substance called anti-nerve growth factor appeared to be more effective in controlling pain in mice than even morphine.

But the work would not have been possible without the new cell line, said Tom Rosol , a co-author of study and a professor of veterinary medicine at Ohio State University.

Armed with this new cell line, researchers will be able to more directly study how prostate cancer affects the body, said Rosol, whose laboratory developed the cell line.

Metastatic bone tumors are a common manifestation in patients with late-stage breast cancer or prostate cancer. "Metastasis" means that cancer has spread from its original site to other areas of the body. But breast cancer typically destroys bone at tumor sites, whereas prostate cancer tumors that spread to bone induce abnormal bone growth.

Currently, most models used to study prostate cancer do not mimic the human condition and the resulting bone metastases. Most of these models really mimic the spread of breast cancer since the bone metastases in that disease are associated with bone loss rather than bone growth.

"Even though there is more bone at the sites of prostate cancer tumors, this formation still damages the bone," said Rosol, who is also dean of the College of Veterinary Medicine at Ohio State . "The new growth compresses nerves, making it terribly painful for the patient".

The results appear in a January issue of the journal Cancer Research. The study was led by Patrick Mantyh, a professor of preventive sciences at the University of Minnesota.........

Mark      Permalink

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    Did you know?
    In the largest study of its kind to date, Mayo Clinic scientists report that prostate specific antigen (PSA) kinetics, both velocity and doubling time, can be used to predict disease progression and likelihood of death after radical prostatectomy surgery, suggesting that this could be used to guide treatment decisions. Study results are published in the December issue of The Journal of Urology.

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