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May 22, 2007, 10:05 PM CT

Patient satisfaction with SYMBICORT

Patient satisfaction with SYMBICORT
New data demonstrated that the combination asthma treatment, SYMBICORT (budesonide/formoterol fumarate dihydrate), led to significant improvements in health-related quality of life (HRQL) and greater patient-reported satisfaction with asthma therapy, versus its monocomponents (budesonide or formoterol) or placebo. The results from these two 12-week randomized, double-blind trials were presented at the American Thoracic Society (ATS) 2007 International Conference held in San Francisco, May 18-23.

"Asthma is a chronic disease that can have a significant effect on patients' day-to-day routine, including participating in activities, such as walking to the store or even playing with their children," said Dr. Kevin R. Murphy, Clinical Professor, University of Nebraska Medical Center. "For the millions of asthma sufferers in the U.S., and particularly for those whose condition is not adequately controlled with their current medication, SYMBICORT will provide a new option for patients to help manage and control their asthma, allowing them to get back to their daily activities".

SYMBICORT is a recently approved, combination treatment indicated for the long-term maintenance therapy of asthma in patients 12 years of age and older. SYMBICORT does not replace fast-acting inhalers and should not be used to treat acute symptoms of asthma. Studies of patients treated with SYMBICORT demonstrated clinically significant improvement in lung function occurring within 15 minutes of beginning therapy. SYMBICORT has safety data in long-term studies of up to one year, and has a robust cardiac safety profile.........

Posted by: JoAnn      Read more         Source

May 21, 2007, 12:14 AM CT

'Healthy' children with smoking parents aren't really so healthy

'Healthy' children with smoking parents aren't really so healthy
Children of smokers who dont show any signs of respiratory problems may still be experiencing damaging changes in their airways that could lead to lung disease during the later part of life, as per a new study presented at the American Thoracic Society 2007 International Conference, on Sunday, May 20.

"Everyone knows that children of smokers have more respiratory problemsmore puffing, wheezing, cases of pneumoniabut until now we havent known if lung function is impaired in children of smokers who dont have any respiratory complaints or diagnosed lung problems," says researcher Bert Arets, M.D., Ph.D., of University Medical Center Utrecht in the Netherlands.

The study included 244 children ages 4 to 12 without any history of lung or airway disease. They were divided into four groups as per the smoking pattern of their parents: never smokers, smoking after birth but not during pregnancy, during pregnancy but not after birth, and both before and after birth.

The scientists observed that children of smoking parents had significantly reduced lung function similar to that seen in smokers. Smoking after birth appeared to be more harmful than smoking during pregnancy alone. The scientists have now expanded their study to include 2,000 healthy children of smokers.........

Posted by: Janet      Read more         Source

May 21, 2007, 12:03 AM CT

Hotter is better for removing allergens in laundry

Hotter is better for removing allergens in laundry
A new study finds that the heat setting you choose when doing laundry makes all the difference when it comes to killing dust mites. The scientists observed that washing laundry in hot water--140 degrees Fahrenheit (60 C) or higher--kills all house dust mites, compared with just 6.5% of dust mites in laundry washed at 104 degrees Fahrenheit (40 C), or warm water. The study is being presented at the American Thoracic Society 2007 International Conference, on Sunday, May 20.

Hotter water temperatures are also more effective in removing dog dander and pollen, says lead researcher Jung-Won Park, M.D., Ph.D., of Yonsei University in Seoul, Korea.

There is an alternative to washing in hot water thats also effective, Dr. Park found: washing at a lower temperature (between 86-104 F, or 30-40 C), then rinsing the laundry twice with cold water for three minutes each.

In the study, scientists compared allergen levels on cotton sheets after they were washed in various temperature settings. They observed that since more pollen was left on the sheets when they were washed in cooler temperatures (86 F, or 30C), rinsing the sheets was particularly important when using this temperature setting.........

Posted by: JoAnn      Read more         Source

May 21, 2007, 11:46 AM CT

House dust may protect against allergic disease

House dust may protect against allergic disease
Endotoxin, a toxic substance made by certain types of bacteria, may reduce the risk of developing the allergic skin condition eczema or wheezing in children if they are exposed to it up to age 3, suggests a study presented at the American Thoracic Society 2007 International Conference, on Sunday, May 20.

Endotoxin is a part of the cell wall of gram-negative bacteria, a type of bacteria that often causes disease. Endotoxin is released when the bacteria dies or is damaged. The new study observed that the lower the amount of endotoxin in young childrens homes, the more likely they were to have wheezing or eczema by age 3. The higher the amount of endotoxin in their homes, the less likely they were to develop either condition by age 3.

Were trying to find why children exposed to endoxotin have lower levels of disease early in life, says researcher Melisa Celaya, M.A., of the Arizona Respiratory Center in Tucson.

Celaya observed that certain environmental factors increased the levels of endotoxin in a home: having a home older than 30 years, substandard home conditions, carpeting, a musty smell and interior wall leaks were all linked to higher levels of endotoxin.

Blood samples were taken from 484 children enrolled in the Infant Immune Study at different ages, up to 5 years of age. We will be looking at the relationship between endotoxin levels in the home and chemicals (called cytokines) that are produced by certain immune system cells, to see why children exposed to lower levels are in the process of developing more allergic symptoms later on, she says. This study is unusual in that we are following children over a long period, and are looking at both environmental factors and immunological factors, so we can correlate the two.........

Posted by: JoAnn      Read more         Source

May 17, 2007, 5:30 AM CT

Asthma patients have more options

Asthma patients have more options
People with mild asthma that is well-controlled with twice-daily use of inhaled steroids may be able to reduce inhaler use to once a day or switch to a daily pill as per new research conducted at Wake Forest University Baptist Medical Center and 20 other centers.

"This is good news for patients with mild, persistent asthma because it gives them more choices about how to manage their disease," said Stephen P. Peters, M.D., Ph.D., lead author and a professor of pediatrics, internal medicine-pulmonary and associate director of the Center for Human Genomics.

The study, involving 500 children and adults with mild asthma, was conducted by the American Lung Associations Asthma Clinical Research Centers. Its goal was to determine if patients whose symptoms are well controlled on twice daily inhaled corticosteroid can "step down" their medicine use. The results are published in the May 17 issue of the New England Journal (NEJM).

Asthma is considered mild, but persistent, when symptoms occur more than two times a week or cause the patient to awaken during the night more than twice a month. The standard therapy for mild-persistent asthma is twice-daily use of an inhaled steroid to prevent symptoms. Patients may also take additional drugs such as the inhaler albuterol, known as "rescue" treatment, to treat symptoms. A majority of people with asthma have mild disease, as per Peters.........

Posted by: JoAnn      Read more         Source

May 9, 2007, 11:26 PM CT

Coarse particulate matter in asthma sufferers

Coarse particulate matter in asthma sufferers
Breathing air containing coarse particulate matter such as road or construction dust may cause heart problems for asthma sufferers and other vulnerable populations, as per a new study led by the University of North Carolina at Chapel Hill School of Public Health.

The scientists observed that in people with asthma, a small increase in coarse particulate matter in outdoor air raised bad cholesterol and increased the count of inflammation-linked white blood cells, among other changes.

"This research was all done with study participants just being outside and breathing outdoor air," said Dr. Karin Yeatts, research assistant professor of epidemiology at the UNC School of Public Health, a member of the UNC Center for Environmental Medicine, Asthma and Lung Biology, and the study's principal investigator. "Our results indicate that susceptible people really need to pay attention to air pollution warnings and stay inside when the air pollution is bad. This is especially the case for people with asthma".

The study, reported in the May 2007 issue of Environmental Health Perspectives, was a collaboration by scientists from the School of Public Health, the School of Medicine's Center for Environmental Medicine, Asthma and Lung Biology and the U.S. Environmental Protection Agency (EPA).........

Posted by: JoAnn      Read more         Source

April 30, 2007, 8:28 PM CT

Protecting Infants Against Future Allergies

Protecting Infants Against Future Allergies
Maybe being a fussy housekeeper isn't such a good thing after all.

Environmental health researchers at the University of Cincinnati (UC) say they have confirmed what other researchers have only suspected: early-life exposure to certain indoor fungal components (molecules) can help build stronger immune systems, and may protect against future allergies.

The UC team observed that infants who were exposed to high levels of indoor fungal components-known as fungal glucans-were nearly three times less likely to wheeze compared with infants exposed to low levels.

Fungal glucans are tiny molecules that researchers believe cause respiratory symptoms in adults. Crawling infants are often exposed to these molecules when they disturb dust on carpet or floors in their homes.

Study lead author and environmental health scientist Yulia Iossifova says exposure to high levels of these molecules may also protect against allergy development in high-risk infants.

"The immune system's protective effects only appear to occur when there are high levels of microbial exposure," she explains. "Cleaner environments do not have enough microbial components to trigger the immune system response."

The UC team reports their findings in the May 2007 edition of the scientific journal Allergy. This epidemiological study is the first to suggest that early-life exposure to high levels of indoor fungal glucans can have a positive impact on the human immune system.........

Posted by: JoAnn      Read more         Source

April 3, 2007, 10:43 PM CT

Allergic Diseases and Autoimmune Diseases

Allergic Diseases and Autoimmune Diseases
A new study by scientists at Children's and the University of Washington (UW) identifies a correlation between allergic diseases such as atopic dermatitis, also known as eczema, and autoimmune diseases. The study was reported in the April 1 edition of Nature Immunology.

Approximately 75 percent of autoimmune diseases occur in women, most frequently during the childbearing years. These diseases also comprise a significant portion of chronic childhood disorders. Autoimmune disease refers to a group of more than 80 serious, chronic illnesses including diseases of the nervous, gastrointestinal, and endocrine systems as well as skin and other connective tissues, eyes, blood, and blood vessel. In all of these diseases, the underlying problem is similar-the body's immune system (including B and/or T immune cells) becomes misdirected, attacking the very organs it was designed to protect.

"Our study implies that allergic and inflammatory diseases may actually trigger autoimmune diseases by relaxing the controls that normally eliminate newly produced, self-reactive B cells. This is important because a number of autoimmune diseases are caused by self-reactive antibodies produced by such B cells" said Dr. David Rawlings lead researcher and section head of Immunology at Children's Hospital and the UW.........

Posted by: JoAnn      Read more         Source

February 24, 2007, 8:46 PM CT

Symbicortand Improves Lung Function

Symbicortand Improves Lung Function
Wilmington, DE February 24, 2007 New data demonstrated the maintenance combination asthma treatment, SYMBICORT (budesonide/formoterol fumarate dehydrate), provides a rapid, clinically significant bronchodilatory response, or opening of the airways, defined as the median time to achieve ≥15% improvement in lung function within 15 minutes after administration. In addition, these data demonstrated that compared to its monocomponents (budesonide and formoterol) and placebo, SYMBICORT and the other therapy groups containing formoterol had a faster bronchodilatory response than budesonide or placebo. The combined study results, involving patients with mild-to-severe persistent asthma who previously mandatory therapy with inhaled corticosteroids (ICS), were presented today at the annual meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI) held in San Diego, February 23-27, 2007.

SYMBICORT is a newly approved, twice-daily, inhaled combination treatment containing budesonide, a corticosteroid, and formoterol, a rapid and long-acting beta2-agonist. It is indicated for the long-term maintenance therapy of asthma in patients ages 12 and older. SYMBICORT is not indicated in patients whose asthma can be successfully managed by inhaled corticosteroids along with occasional use of inhaled, short-acting beta2-agonists.........

Posted by: JoAnn      Read more         Source

November 2, 2006, 4:59 AM CT

Intact Tonsils Triple Risk Of Recurrent Strep Throat

Intact Tonsils Triple Risk Of Recurrent Strep Throat
Children with recurrent strep throat whose tonsils have not been removed are over three times more likely to develop subsequent episodes of strep throat than children who undergo tonsillectomy, as per a Mayo Clinic study reported in the Nov. 2 issue of Laryngoscope.

"These results suggest that tonsillectomy is a useful treatment for treating children with recurrent strep throat infections," says Laura Orvidas, M.D., Mayo Clinic ear, nose and throat surgeon and senior study investigator. "It should decrease the amount of infections experienced by this subset of children and therefore diminish the number of missed school days and hopefully improve overall quality of life".

Dr. Orvidas and his colleagues conducted a population-based retrospective cohort study of children between ages 4 and 16 who received three or more diagnoses of strep-correlation tonsillitis or pharyngitis at least one month apart, within 12 months. Within this group, children who subsequently underwent a tonsillectomy were compared with an age- and sex-matched sample of children who had not had a tonsillectomy. The date of the tonsillectomy for the matched pair was defined as the index date. All strep infections were recorded for each of these two groups of children.

The study population comprised 290 children (145 who received a tonsillectomy and 145 who did not). In the tonsillectomy group, 74 children experienced at least one strep infection after the index date and before age 16. Among those who did not receive a tonsillectomy, 122 experienced at least one strep infection during the follow-up. The time before first subsequent strep infection was much longer for those who had a tonsillectomy, a median of 1.1 years as in comparison to 0.6 years for children whose tonsils had not been removed. By one year after the index date, the cumulative occurence rate of a strep infection was 23.1 percent among the children who had a tonsillectomy in comparison to 58.5 percent among the children who had not.........

Posted by: JoAnn      Permalink         Source

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Did you know?
Scientists at Yale have brought to light a mechanism that regulates the way an internal organelle, the Golgi apparatus, duplicates as cells prepare to divide, according to a report in Science Express.Graham Warren, professor of cell biology, and colleagues at Yale study Trypanosoma brucei, the parasite that causes Sleeping Sickness. Like a number of parasites, it is exceptionally streamlined and has only one of each internal organelle, making it ideal for studying processes of more complex organisms that have a number of copies in each cell. Archives of allergy news blog

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