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Feb 9, 2006

Linda Nolan Has Breast Cancer

Linda Nolan Has Breast Cancer
Former pop singer and West End stage star Linda Nolan has been diagnosed with breast cancer. Nolan, who is 46 years old, who was diagnosed with breast cancer last week told reporters that it was shocking and is still trying to adjust the reality. Yet she is trying to be as positive as possible

Nolan said: "I know this is something that affects so many women and like them, all I can do is stay as positive as possible."

Spokeswomen for the singer confirmed that Nolan is due to start her treatment. Dublin-born. She said: "I can confirm that, yes, Linda has got breast cancer and she will be going into treatment."

Nolan made her stage debut at the age of four and the family act eventually achieved international success, touring Europe with Frank Sinatra, and with their own BBC TV Specials.

In her solo career, she has toured with Gene Pitney, and was voted Female Vocalist of the Year in 1990 for her cabaret show.

Nolan has been married to Brian Hudson, her manager, since 1981 and the couple live in London.

Janet      Permalink

Feb 7, 2006

How Broccoli May Protect You From Cancer

How Broccoli May Protect You From Cancer
Make broccoli a part of your everyday diet. This may protect you from cancer. A chemical found in vegetables such as broccoli, cauliflower and cabbage might boost DNA repair in cells that may have undergone damage. Previous research has shown a link between these foods and a reduced cancer risk. Now a new research is showing how these vegetables might decrease your risk of cancer.

These research findings are published in the latest issue of the British Journal of Cancer.

The protective effects of broccoli and other vegetables are attributable to the presence of a compound called I3C. During the normal process of growth and development DNA damages may occur. It is vital to repair these genetic defects and preventing it to pass to the daughter cells at the time of cell division.

The compound that is present in broccoli and other vegetables (13C) helps in the repair of damaged DNA. BRCA1 BRCA2, are genes that make proteins that help to repair DNA damage. These proteins helps to repair the genetic defects and prevent damaged genetic information being passed on to the next generation of cells. Those who have faulty genes like BRCA1 at BRCA2 may have a high of developing breast cancer and other types of the cancer.

Cancer cells usually have very low levels of BRCA proteins, so the scientists assume that higher levels might prevent cancer from developing. Researchers say that ability of I3C to boost the amount of BRCA proteins could explain their protective effects.

Janet      Permalink

Feb 7, 2006

Eating Less Fat May Not Protect You From Cancer And Heart Disease

Eating Less Fat May Not Protect You From Cancer And Heart Disease

Eating less fat is not final solution cancer and heart disease as per findings from a recently published research. This new study has found that eating less fat later in life may not lower the risk of cancer and heart disease among older women. This is a disappointment for those who expected to have a greater benefit from a healthy diet.

These results come from a large study, sponsored by the government. A total of 48,835 women participated in this study. Researchers say that this is not the final decision regarding benefits of low fat diet.

Researchers argue that these women may have started this low-fat diet too late in their life to derive any benefit. Average age of patients participated in the study was 62 years. The researchers also point out that these women did not reduce the intake of fat as much as the diet demanded. Most of these women remained overweight during the course of the study, a major risk factor for cancer and heart problems.

This study, which has lasted eight years, showed no difference in the rate of breast cancer, colon cancer and heart disease among those who ate lower-fat diets and those who didn't.

Heart and cancer specialists said that thy were not very much surprised by the study results since scientific thinking on the role fats play in disease prevention has evolved since this study was designed. That is especially true when it comes to good and bad fats and heart disease.

Sue      Permalink

Feb 6, 2006

Proteins That Work With Estrogen To Promote Breast Cancer

Proteins That Work With Estrogen To Promote Breast Cancer
Some new proteins may work in partnership with estrogen to promote breast cancer. Researchers have identified a group of proteins that may work in partnership with estrogen to increase the risk of breast cancer. One such protein known as c-MYC is known to be associated with increased risk of cancer. However this is the first time a protein is the shown to interact with estrogen to increase the risk of breast cancer.

The study was conducted by researchers from Ohio State University Comprehensive Cancer Center. They are trying to answer the puzzling question of how estrogen can turn on some genes and turn off others during cancer progression.

Researchers, Ramana V. Davuluri and colleagues have found that estrogen may interact with seven different partner proteins to increase the risk of breast cancer. These new findings could lead to development of potential new drug targets and may now open the doors for new tests to identify breast-cancer patients with tumors that are likely to become resistant to hormonal therapies such as tamoxifen and aromatase inhibitors.

This new research is published in the recent issue of the journal Molecular Cell.

This study stands out of the crowd, because of the fact that the study used microarray technology and mathematical modeling to predict which cell proteins work with estrogen to contribute to breast cancer development, and then used more traditional experimental biology to verify one of the predictions.

Sherin      Permalink

Feb 1, 2006

How Breast Cancer Affects Your Job

How Breast Cancer Affects Your Job
Did your employer make reasonable accommodation for your breast cancer, while you were ongoing the treatment? If your answer is yes then you are in the majority. There is now information on this issue thanks to the research efforts of Dr. Reynard R. Bouknight and colleagues from Michigan State University in East Lansing. His study has shown that most women who are diagnosed with breast cancer return to work after completion of treatment of breast cancer. Dr. Bouknight says that it always helps to have an understanding and accommodating employer.

The study has found that 80 percent of women who have been diagnosed with breast cancer return to the same job she was having prior to the diagnosis. This indicates that these women are enjoying excellent health after completion of their treatment.

The study included 416 employed women, who have been diagnosed with breast cancer. These women were interviewed 12 and 18 months after being diagnosed with breast cancer.

Bouknight and colleagues found that Employer workplace accommodation was the most important factor that determined the return of the woman to the same job.

As per the perception of women who have been diagnosed with breast cancer, 87 percent of employers were willing to accommodate their treatment needs. Those women, who thought that their employers were not supportive, were less likely to return to work.

If you are interested in reading the whole study, you can find it the latest issue of the Journal of Clinical Oncology.

Sherin      Permalink

Jan 31, 2006

Cancer Care Varies From Place To Place

Cancer Care Varies From Place To Place

American health system provides good care for the cancer patients, however the type of care varies from place to place as per a new study. In a study published in the Journal of Clinical Oncology, the researchers say that, breast and colorectal cancer patients were given nearly all of the therapies recommended by experts.

This study, which was sponsored by the American Society of Clinical Oncology, examined the care of nearly 1,800 patients in Atlanta, Cleveland, Houston, Kansas City, Kan., and Los Angeles.

This study examined a broad range of therapies in two of the most common malignancies: 36 for breast cancer and 25 for colorectal cancer. Researchers found that doctors followed some guidelines more closely than others. Researchers have found that, among newly diagnosed breast cancer patients, 99% had their lymph nodes tested. But only 6% of patients who had higher risk of breast caner recurrence actually saw a radiation oncologist.

Researchers also noted wide variations from one hospital to another. For patients who have surgery for rectal cancer, experts say doctors should record whether tumor cells have spread to the lymph vessels or blood vessels. Within a single city, however, the percentage of patients whose doctors took this step was 13% to 99%, according to the study. The report's authors did not identify the city.

Janet      Permalink

Jan 28, 2006

Passive Smoking, Breast Cancer Link

Passive Smoking, Breast Cancer Link
We have discussed the link between passive smoking and risk of breast cancer in this blog earlier. Now there is legal backing for this argument.

Regulators in California have recently ruled that secondhand smoke increases the risk for breast cancer in younger women. This is an unprecedented finding that could lead to tougher anti-smoking measures.

This ruling was approved by the state's Air Resources Board, which is well known nationally for its tough stance on limiting auto and diesel pollution. The board has unanimously approved a 1,200-page report from California Environmental Protection Agency scientists report citing that secondhand smoke increases the risk of breast cancer in younger women. The agency's findings challenged conventional scientific community which until recently considered the link between female smoking and breast cancer is based on scanty evidence.

"I think that if we don't embrace these new conclusions, we're doing a disservice to younger women," says Andrew Hyland, a research scientist at the Roswell Park Cancer Institute in Buffalo. "My prediction is that in the months to come, people will see the evidence and change their opinion."

By accepting the environmental protection agencies finding, the Air Resources Board officially lists secondhand smoke as a "toxic air contaminant" under state law. That begins a process that could lead to new restrictions in the state that already has the nation's toughest anti-smoking rules. Those could include reducing exposure in vehicles carrying children or in rental buildings where smoke drifts from apartments with smokers to non-smokers' units.

Sherin      Permalink

Jan 26, 2006

Doctor Apologizes For Mammogram Mistakes

Doctor Apologizes For Mammogram Mistakes
Ar. Amjad Khan, who consultant radiologist is in deep trouble after missing diagnosis of breast cancer in 22 women for whom he was reading the mammograms. He was working at Trafford General Hospital, UK, when this incidence occurred. These 22 women were told much later that they had breast cancer in their mammograms that were taken previously.

An investigation was quickly enforced and experts combed through nearly 2,500 mammograms handled by the consultant at the two hospitals. They found that reading by this radiologist contained significant errors. About 176 patients were recalled to have repeat mammogram and among 28 were found to have some form of breast cancer. Twenty-one had been diagnosed with breast caner and one had treatable tumor. Dr Husien was suspended from working in the Trafford, Greater Manchester, after staff questioned his work.

In a statement released by Greater Manchester Strategic Health Authority on Thursday, Dr Husien said: "I deeply regret any distress or suffering experienced by patients and their relatives arising from this review.

Health managers have admitted some of the women could die because of mistakes made from April 2003.

Women undergo mammogram in an effort to find breast cancer early, and mistakes like this which defeats the purpose of mammogram can't be tolerated. The pain and misery caused to these 22 women who had significant delays in their breast cancer diagnosis can't be amply compensated by any action by the authorities.

Sherin      Permalink

Jan 25, 2006

Breast Cancer Increasingly Found At Early Stage

Breast Cancer Increasingly Found At Early Stage
Diagnosis of early stage breast cancer shows a dramatic increase in UK since last five years. Reports say that incidence of earliest form of breast cancer, known as ductal carcinoma in situ, has increased to 3,800 compared to 2,910 that was found five years ago. Experts suggest that this increase is due to finding of a number of new cases due to mammogram screening and argue that these cases of breast cancer would have been missed, if mammogram screenings were not done.

Release of these numbers has particular significance. The figures were announced at the start of a worldwide study to investigate which of two breast cancer drugs, the old gold standard treatment tamoxifen or the new treatment, anastrozole, is better at preventing the dis-ease from returning in women who have already had DCIS.

This Ibis-2 study aims to recruit 10,000 women, 4,000 of who have been diagnosed with DCIS.

Concern about the rise in cases of DCIS has led some doctors to criticize the mammogram screening program for increasing anxiety and subjecting women to unnecessary treatment without extending their lives.

A study published in the British Medical Journal in 2003 said breast screening was contributing to a rise in the incidence of breast cancer and resulted in mastectomies that may have been unnecessary for the women and expensive for the health service.

Sherin      Permalink

Jan 22, 2006

Female Hormone Levels Don't Predict Breast Cancer

Female Hormone Levels Don't Predict Breast Cancer
Higher blood level of a female hormone, namely estradiol, don't increase risk of developing breast cancer, as per findings from a new study.

Many studies in the past have suggested a positive relationship between higher levels of estradiol and increased risk of developing breast cancer in postmenopausal women. One study had found that raloxifen, which is selective estrogen receptor modulator (SERM) similar to commonly used tamoxifen may be a better option for postmenopausal women, who has higher levels of estradiol.

Mary S. Beattie, M.D., of the University of California in San Francisco, and colleagues examined the levels of sex hormones estradiol and testosterone, and sex hormone-binding globulin in the blood plasma of 135 postmenopausal women with breast cancer and 275 postmenopausal control women who had been treated with tamoxifen or placebo as part of a breast cancer prevention trial. The authors sought to determine whether sex hormone levels are associated with breast cancer risk, and whether breast cancer risk reduction varied by sex hormone level among women on tamoxifen, which is also a SERM.

Their results showed that levels of sex hormones were not associated with breast cancer risk in these women and cannot be used as a predictor for breast cancer risk or determine who would most benefit from tamoxifen treatment. Tamoxifen had the same effect on breast cancer risk in women with high and low levels of estradiol. The authors suggest that the study should be repeated in other populations with a high risk of developing breast cancer.

Sherin      Permalink

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Breast cancer
Every year, more than 200,000 women are diagnosed with breast cancer in the United States. Breast cancer ranks second as the leading cause of cancer deaths in American women. Until recently breast cancer topped the list of leading causes of cancer deaths in women, but lately lung cancer has claimed the top position. If skin cancer is excluded, breast cancer is the commonest cancer among American women. Archives of breast-cancer-blog

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