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Archives Of Breast-cancer-blog From Medicineworld.Org

June 11, 2007, 3:52 PM CT

Diet and Exercise Keyto Surviving BreastCancer

Diet and Exercise Keyto Surviving BreastCancer
Breast cancer survivors who eat a healthy diet and exercise moderately can reduce their risk of dying from breast cancer by half, regardless of their weight, suggests a new longitudinal study from the Moores Cancer Center at the University of California, San Diego (UCSD).

Prior studies have looked at the impact of diet or physical activity on breast cancer survival, with mixed results. This study, reported in the June 10 issue of the Journal of Clinical Oncology, is the first to look at a combination of both in breast cancer.

"We demonstrate in this study of breast cancer survivors that even if a woman is overweight, if she eats at least five servings of vegetables and fruits a day and walks briskly for 30 minutes, six days a week, her risk of death from her disease goes down by 50 percent," said the paper's first author, John Pierce, Ph.D., director of the Cancer Prevention and Control Program at the Moores UCSD Cancer Center. "The key is that you must do both".

The study looked at 1,490 women aged 70 years and younger (average 50 years) with early stage breast cancer who were randomly assigned to the non-intensive dietary arm of the ongoing Women's Health Eating and Living (WHEL) study. The WHEL study is a multi-center study, based at UCSD, investigating the effect of a plant-based diet on additional breast cancer events.........

Posted by: Janet      Read more         Source

May 21, 2007, 10:45 AM CT

Keeping pain and fatigue on the run

Keeping pain and fatigue on the run
Women diagnosed with breast cancer should either get exercising or keep exercising. This is the message from a new study in Springer's Journal of Cancer Survivorship by Catherine Alfano and his colleagues at the Ohio State University1. The study of over 500 women who had survived breast cancer highlights how physical activity, and more specifically the intensity and amount of physical activity you do before and after cancer therapy, can affect future symptoms and your quality of life.

Cancer symptoms and those brought on by its therapy can have a huge impact on everyday life. Physical symptoms usually include fatigue, post-surgery pain, hormone-related symptoms in-cluding hot flashes, sweats, palpitations, urinary incontinence and cognitive and mood changes. Psychological effects such as anxiety and depression are also common. Physical symptoms exacerbate anxiety as they are a constant reminder of the cancer and add to the worry about whether it will recur. Some of these symptoms are seen in cancer survivors as long as 20 years after the cancer has gone.

Participants in this study from New Mexico and western Washington were asked to score their lev-els of pain and physical sensation, hormone-related symptoms, sexual interest/dysfunction, fatigue and physical health-related quality of life at 6, 29 and 39 months post-diagnosis. They were also asked to quantify their physical activity levels based on household activity, moderately vigorous activity, vigorous activity and sports/recreational activity at these times. The authors expected to see higher levels of activity being correlation to fewer physical symptoms and higher health-related quality of life.........

Posted by: Janet      Read more         Source

May 6, 2007, 5:47 PM CT

Computer-aided detection of breast cancer

Computer-aided detection of breast cancer
The use of computer-aided detection (CAD) with computed radiography (CR) is effective in the detection of breast cancer, as per a recent study conducted by radiologists at George Washington University Medical Center in Washington, DC and iCAD in Nashua, NH.

"I wanted to undertake this study because we need to further define the performance of CAD with CR," said Rachel Brem, MD, lead author of the study. "There is no doubt that CR will be an increasingly important technology in breast imaging and multiple studies have unequivocally demonstrated the improved detection of breast cancer with CAD. Therefore, we wanted to investigate these two technologies' synergies," she said.

The study included 53 cases with breast cancer that were reviewed using a CAD system. The scientists assessed the sensitivity of cancer detection by CAD, and the mammmographic density as well as cancer sizes.

The study showed that 47 of 53 cancer cases were detected by CAD (30 cancers in non dense breasts and 17 cancers in dense breasts). As per the study results, CAD detected 11 of 12 cancers manifesting as calcifications and 36 out of 41 masses.

"CAD had a high sensitivity of 89% with CR mammography that was maintained even in conditions that may lower the sensitivity of mammography, such as dense breasts and small lesions one millimeter or less," said Dr. Brem.........

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April 25, 2007, 9:41 PM CT

New hereditary breast cancer gene discovered

New hereditary breast cancer gene discovered
A new hereditary breast cancer gene has been discovered by researchers at the Lundberg Laboratory for Cancer Research and the Plastic Surgery Clinic at the Sahlgrenska Academy in Sweden. The scientists observed that women with a certain hereditary deformity syndrome run a nearly twenty times higher risk of contracting breast cancer than expected.

Several research teams around the world have long been searching for new hereditary breast cancer genes, but thus far few have been found.

"Our findings are extremely important, providing new knowledge of hereditary cancer genes and how they can cause breast cancer. The discovery also makes it possible to uncover breast cancer in women who have a predisposition for Saethre-Chotzen malformation syndrome," says Gran Stenman.

By detailed mapping of families with Saethre-Chotzen syndrome, the Gteborg researchers have now observed that women with this syndrome have an elevated risk of contracting breast cancer. Saethre-Chotzen is a syndrome that primarily involves malformations of the skull, face, hands, and feet. The syndrome is caused by mutations in a gene called TWIST1.

"Our findings show that women with this syndrome run a nearly twenty times greater risk of contracting breast cancer than expected. Moreover, a number of of the women were young when they were affected by breast cancer," says Gran Stenman.........

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March 29, 2007, 4:59 AM CT

Breast Cancer Patients For Reconstruction

Breast Cancer Patients For Reconstruction
Forty-four percent of surgeons do not refer the majority of their patients with breast cancer to a plastic surgeon previous to the initial surgery when the woman is choosing her therapy course, as per a new study by scientists at the University of Michigan Comprehensive Cancer Center.

The finding may help explain the consistently low number of women who pursue breast reconstruction after mastectomy.

The scientists surveyed 365 surgeons, asking them how often they referred patients considering a mastectomy to a plastic surgeon before performing the mastectomy. The surgeons were identified from a population-based database of women in the Detroit and Los Angeles metropolitan areas who had been treated for breast cancer.

The study found 44 percent of the surgeons referred fewer than a quarter of their patients to a plastic surgeon previous to the mastectomy. Only 24 percent of surgeons referred three-quarters or more of their patients for reconstruction.

The study appears March 26 in the online edition of the journal Cancer.

"Women may be more inclined to choose mastectomy with a good understanding of the reconstructive options. We need to help patients through this difficult decision-making process up front, through patient decision aids that include information about reconstruction and multidisciplinary approaches to care, where all surgical options are fully explained," says lead study author Amy Alderman, M.D., M.P.H., assistant professor of plastic surgery at the U-M Medical School.........

Posted by: Janet      Read more         Source

March 28, 2007, 10:21 PM CT

MRI Detects Most Missed Opposite Breast Cancers

MRI Detects Most Missed Opposite Breast Cancers
Up to 10 percent of women newly diagnosed with cancer in one breast develop cancer in the opposite breast. Results of a major clinical trial show that magnetic resonance imaging (MRI) scans are highly effective tools for quickly identifying these opposite breast cancers, detecting diseased tissue that other screening methods missed.

In the new trial, conducted by the American College of Radiology Imaging Network (ACRIN) and funded by the National Cancer Institute, scientists wanted to determine whether MRI could improve doctors' ability to identify these opposite breast cancers right at the initial diagnosis - boosting the chances for swift and successful therapy.

The results, reported in the New England Journal (NEJM), show that for women already diagnosed with cancer in one breast, MRI scans detected more than 90 percent of cancers in the opposite, or contralateral, breast.

"The study establishes MRI as a key component of the diagnostic workup for women with breast cancer," said Constantine Gatsonis, lead statistician for the trial and director of the Center for Statistical Sciences at Brown University. "If my wife were diagnosed with breast cancer, I'd be sure that she got an MRI of the opposite breast".

Gatsonis, a Brown professor of biostatistics, oversaw design of the MRI trial and led analysis of its results. He offered a caveat: The study showed that MRI is an effective addition to - but not a replacement for - clinical breast exams and mammography.........

Posted by: Janet      Read more         Source

March 19, 2007, 5:10 AM CT

Smart Therapies For Breast, Ovarian Cancer

Smart  Therapies For Breast, Ovarian Cancer
New non-toxic and targeted therapies for metastatic breast and ovary cancers may now be possible, thanks to a discovery by a team of scientists at the University of British Columbia.

In a collaboration between UBC stem cell and cancer scientists, it was observed that a protein called podocalyxin which the scientists had previously shown to be a predictor of metastatic breast cancer changes the shape and adhesive quality of tumour cells, affecting their ability to grow and metastasize. Metastatic cancer is invasive cancer that spreads from the original site to other sites in the body.

The discovery demonstrated that the protein not only predicted the spread of breast cancer cells, it likely helped to cause it. The findings were recently published online by the Public Library of Science.

"We believe weve found a new important culprit in metastatic breast cancer, which opens up an entirely new avenue of cancer research," says Calvin Roskelley, an associate professor of cellular and physiological science who specializes in breast cancer and is co-senior principal investigator. "The culprit is hiding in plain sight on the surface of tumour cells, so we are now developing "smart" molecules to block its function. The ultimate goal is to generate new targeted, non-toxic therapys very different from the standard slash and burn chemotherapy".........

Posted by: Janet      Read more         Source

March 6, 2007, 3:43 PM CT

Probe To Detect Spread Of Breast Cancer

Probe To Detect Spread Of Breast Cancer Physicist Audrius Brazdeikis, right, London surgeon Dr. Michael Douek, left
Credit: Mark Lac
High-temperature superconductors hold the key to a handheld tool for surgeons that promises to be more accurate, cost-effective and safer than existing methods for staging and treating various cancers, including breast cancer.

Audrius Brazdeikis, research assistant professor of physics in the College of Natural Sciences and Mathematics at the University of Houston, and Quentin Pankhurst, a professor of physics from the University College of London (UCL), have developed a novel detection procedure combining nanotechnology and advanced magnetic sensing based on high-temperature superconductors. Their innovation will enable surgeons to more effectively locate the sentinel lymph node the first lymph node to which a tumors metastasizing cancer cells will drain.

The scientists produced an ultrasensitive magnetic probe to detect minuscule magnetic fields in the body. The probe is a supersensitive magnetometer an instrument used to track the presence of clinically introduced magnetic nanoparticles. During breast cancer surgery, a surgeon will inject a magnetic nanoparticle dye, already approved as an imaging contrast agent by the Food and Drug Administration, into the tumor or into tissues surrounding the tumor.

Receiving a $250,000 grant to be used from 2004 to 2006 from the United Kingdom Department of Trade and Industry under the UK-Texas Bioscience Collaboration Initiative, Brazdeikis and Pankhurst were mandatory to show "proof of concept" by building a device and showing it worked. An ethics committee in the UK since has approved the detection procedure for a clinical trial of women undergoing breast cancer surgery at University College Hospital, London.........

Posted by: Janet      Read more         Source

February 26, 2007, 8:49 PM CT

Creating New Life Forms to fight cancer

Creating New Life Forms to fight cancer
Instead of using the usual cancer-fighting modalities, surgery, chemotherapy, or radiation, researchers from a drug development company called Advaxis, have embarked on a novel approach to fighting cancer: Engaging the immune system to attack cancer in the same the way it would a flu vaccine, by creating new life forms.

Dr. Vafa Shahabi, Advaxis' Director of Research and Development, reports that because the human immune system is not designed to fight cancer on its own, she and her colleagues are trying to harness its power through a new kind of life form: specifically a family of vaccines, which they call Lovaxin. The vaccines are comprised of new strains of bacteria created in Advaxis' laboratory that are programmed to kill off specific cancers.

The Key: A Microbe Found in Dairy Products Central to this startling discovery is the microbe Listeria monocytogenes, a common bacterium found in milk, cheese and other dairy products. This microorganism apparently aids in fighting cancer by activating the body's own killer (cytotoxic T) cells to elicit a stronger than normal immune response to the presence of cancer cells. The vaccines "teach" the immune system to mount a specialized, targeted response that is lethal to cancer.

When Listeria is introduced in the body, it has a powerful, direct stimulatory effect on the activities of tumor-killing T cells. "Essentially the modified Listeria vaccines harness the power of the immune system against this infectious agent," explains Dr. Shabahi, "and then directs it to successfully attack cancer cells. The bacterium in effect then becomes a cancer-fighting 'Trojan horse,' with the enemy tucked inside."........

Posted by: Janet      Read more         Source

February 21, 2007, 9:45 PM CT

Taxol chemotherapy in breast cancer

Taxol chemotherapy in breast cancer
Cancer scientists at Georgetown University Medical Center have taken a step towards understanding how and why a widely used chemotherapy drug works in breast cancer patients.

In laboratory studies, the scientists isolated a protein, caveolin-1, showing that in breast cancer cells this protein can enhance cell death in response to the use of Taxol, one of two taxane chemotherapy drugs used to treat advanced breast and ovary cancer. But in order to work, they found the protein needs to be "switched on," or phosphorylated. The results were published in the current (February 23) issue of the Journal of Biological Chemistry.

Their finding suggests it may eventually be possible to test individual patients with breast cancer for the status of such molecular markers as caveolin-1 in their tumors to determine the efficacy-to-toxicity ratio for Taxol, said the studys first author, postdoctoral fellow Ayesha Shajahan, Ph.D., of Lombardi Comprehensive Cancer Center at Georgetown.

"Because breast tumors are not all the same, it is important to know the cancers molecular makeup in order to increase the efficiency, and lower the toxicity, of chemotherapy drugs, and this work takes us some steps forward in this goal," she said. "It also offers insights into why some breast cancer cells can become resistant to therapeutic drugs".........

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Breast cancer
Every year, more than 200,000 women are diagnosed with breast cancer in the United States. Breast cancer ranks second as the leading cause of cancer deaths in American women. Until recently breast cancer topped the list of leading causes of cancer deaths in women, but lately lung cancer has claimed the top position. If skin cancer is excluded, breast cancer is the commonest cancer among American women. Archives of breast-cancer-blog

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