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Doctors say that hormone therapy may lead to high rate of heart disease in men with prostate cancer as per findings of this research published in the journal Cancer.
Dr. Shehzad Basaria from Johns Hopkins University say that heart disease is one of the most common causes of death in men with prostate cancer. In a study of 53 men with prostate cancer, the researchers found that those treated with hormonal therapy for at least one year were more resistant to the action of insulin, and had higher glucose levels than men who had only received local surgery and or radiation and had normal testosterone levels, and age-matched healthy men with normal testosterone levels.
According to the study, 44 percent of men in the hormone therapy group had blood sugar levels greater than 126, which is among the criteria for the diagnosis of diabetes. In contrast, only about 12 percent of men in the other groups had blood sugar levels this high.
Feb 10, 2006
Do You Read All Of Our Medical Blogs?
Breast cancer blog: Breast cancer blog is run by Janet and colleagues. Latest post from this breast cancer blog reads as follows: Linda Nolan Has Breast Cancer - Former pop singer and West End stage star Linda Nolan has been diagnosed with breast cancer. Nolan, who is 46 years old, who was diagnosed with breast cancer last week told reporters that it was shocking and is still trying to adjust the reality. Yet she is trying to be as positive as possible......
Lung cancer blog: Lung cancer blog is run by Scott and colleagues. Latest post from this lung cancer blog reads as follows: Do You Read All Of Our Medical Blogs? - Do you read all of the medical blogs published by medicineworld.org? Many of our bloggers are busy keeping you updated on various medical topics. Medicieworld.org is publishing a wide variety of blogs on different topics.......
Colon cancer blog: Colon cancer blog is run by Sue and colleagues. Latest post from this cancer blog post reads as follows: Cancer Death Rate Finally Falls - For the first time in 70 years the cancer death rate has actually declined in the United States. This may be an indication that we are winning the war on cancer and this point in time may very well represent a dramatic turning point in the history of cancer...............
Prostate cancer blog: Prostate cancer blog is run by Mark and colleagues. Latest post from this prostate cancer blog reads as follows: Vitamin D May Inhibit Prostate Cancer - Vitamin D may have the ability to inhibit the spread of prostate cancer cells by limiting the activity of two specific enzymes as reports University of Rochester Medical Center researches.......
We have a diabetes watch blog as well and this is run by JoAnn and colleagues. The latest post from this diabetes watch blog reads as follows: Eat More Whole Grains To Reduce Risk Of Diabetes - A new study published in the January issue of American Journal of Clinical Nutrition, researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (HNRCA) found that consuming a diet rich in whole-grain foods may lower an elderly person's risk for cardiovascular disease and reduce the onset of metabolic syndrome and diabetes. The term metabolic syndrome is used for a collection of risk factors, puts people at an increased risk of cardiovascular disease and type-2 diabetes.......
Heart watch blog: Heart watch blog is run by Daniel and colleagues. The latest post from this heart watch blog reads as follows: Eat More Whole Grains To Reduce Risk Of Diabetes - ......
Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. The latest post from this cancer blog reads as follows: Cancer Death Rate Finally Falls - For the first time in 70 years the cancer death rate has actually declined in the United States. This may be an indication that we are winning the war on cancer and this point in time may very well represent a dramatic turning point in the history of cancer.......
Feb 9, 2006
Vitamin D May Inhibit Prostate Cancer
Yi-Fen Lee, Ph.D.Vitamin D may have the ability to inhibit the spread of prostate cancer cells by limiting the activity of two specific enzymes as reports University of Rochester Medical Center researches.
This may mean that vitamin D could provide beneficial treatment to prostate cancer patients with high levels of testosterone enzyme.
This research was conducted by Yi-Fen Lee, Ph.D., who is an assistant professor of Urology at the Medical Center and her colleagues and is published in the journal Carcinogenesis.
Past research has suggested that vitamin D suppresses the progression of cancer. This new research has demonstrated that vitamin D significantly limits the ability of prostate cancer cells to invade healthy cells by reducing the activity of two enzymes, proteases called matrix metalloproteinase and cathepsin. Vitamin D also increases the level of counterpart enzymes that inhibit matrix metalloproteinase and cathepsin, the Rochester scientists found.
The researchers did not find any effect of vitamin D on plasminogen activators, which also are important in the spread of prostate cancer. Researchers in this study used 1,25-hydroxylvitamin D3, the most potent and active form of vitamin D in the human body. But Lee and other researchers advised against taking large amounts of vitamin D because it may be associate of the side effects.
Source: University of Rochester
Feb 2, 2006
Corn Oil May Promote Prostate Cancer
This group, known as Omega-6 fatty acids may stimulate growth of prostate cancer cells and the tumor may grow twice as much in the presence of this fatty acid.
Researchers believe that one member of the omega-6 fatty acid family known as arachidonic acid has the capability of turning on a gene that leads directly to tumor growth. This research comes from San Francisco Veterans Administration Medical Center and is published in the latest issue of Cancer Research.
Researchers say that Omega-6 fatty acid by itself doesn't cause cancer directly, but instead acts as a catalyst, for a dormant tumor and promote its growth to full cancer.
These studies were conducted in the laboratory or prostate cancer cell lines and found that cells that are exposed to omega-6 fatty acid grew twice as fast as similar cells not exposed to omega-6.
Jan 28, 2006
Do You Read All Of Our Medical Blogs?
Breast cancer blog: Breast cancer blog is run by Janet and colleagues. Latest post from this breast cancer blog reads as follows: Passive Smoking, Breast Cancer Link - We have discussed the link between passive smoking and risk of breast cancer in this blog earlier. Now there is legal backing for this argument.......
Lung cancer blog: Lung cancer blog is run by Scott and colleagues. Latest post from this lung cancer blog reads as follows: Why Blacks Are More Prone To Lung Cancer? - Given the same amount of exposure to cigarette smoke, the risk of developing lung cancer is much more in blacks compared to the white population. Recent data suggest that this difference in vulnerability for development of lung cancer may be in the genes rather than in the environment.......
Colon cancer blog: Colon cancer blog is run by Sue and colleagues. Latest post from this cancer blog post reads as follows: Fish Oil Good For Heart, But No Help For Cancer - It was widely believed by the scientists and researchers that fish oil may help to prevent some forms of cancer. Fish oil has a known protective effect against heart disease and now it looks like we have to be satisfied with just the heart protective effects of fish oil. This new information on lack of cancer protection of fish oil was released in a review of studies involving more than 700,000 patients...............
Prostate cancer blog: Prostate cancer blog is run by Mark and colleagues. Latest post from this prostate cancer blog reads as follows: Fish Oil Good For Heart, But No Help For Cancer - It was widely believed by the scientists and researchers that fish oil may help to prevent some forms of cancer. Fish oil has a known protective effect against heart disease and now it looks like we have to be satisfied with just the heart protective effects of fish oil. This new information on lack of cancer protection of fish oil was released in a review of studies involving more than 700,000 patients...............
We have a diabetes watch blog as well and this is run by JoAnn and colleagues. The latest post from this diabetes watch blog reads as follows: Teach Your Children Good Eating Habits Early - About 21 million Americans are suffering from diabetes and in addition there are 45 million prediabetics in America. The Centers for Disease Control and Prevention estimate that one out of every three children born in the United States will develop this fatal malady during the course of their life.......
Heart watch blog: Heart watch blog is run by Daniel and colleagues. The latest post from this heart watch blog reads as follows: No Value In Adding Amino Acids After A Heart Attack - Some physicians believed that adding nutritional supplement with amino acids following a heart attack may improve the chances of surviving a heart attack or decreasing the complications related to a heart attack.......
Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. The latest post from this cancer blog reads as follows: Passive Smoking, Breast Cancer Link - We have discussed the link between passive smoking and risk of breast cancer in this blog earlier. Now there is legal backing for this argument...............
Jan 25, 2006
Fish Oil Good For Heart, But No Help For Cancer
Researchers combed through the data from 38 different studies that tracked patients for up to 30 years, and came to the conclusion that omega-3 fatty acids that are present in the fish oil has no cancer protective effect. Dr. Catherine MacLean, the lead author and a researcher at the Rand Corp. and Greater Los Angeles Veterans Affairs Healthcare System say that although a few studies found some risk reduction for cancers of the breast, prostate and lung, those studies were relatively small and not definitive.
I Don't think this is going to be the last word on this issue. It has been shown over and over again that plays a key role in causation and prevention of cancer.
These researchers review includes studies that evaluated the effects of fish oil, in both pill form and as food on 11 kinds of cancer, mostly tumors of the breast, colon, lung or prostate. This new study appear in the latest issue of Journal of the American Medical Association
These 38 studies they have evaluated are very different among themselves involving different population groups and different levels of fish oil consumption. This limits the value of this analysis and precludes from making any definite conclusions.
Jan 24, 2006
Prostate Cancer Patients Often Seek Alternative Therapy
The survey also showed that as many as half of patients who use such alternative therapies don't discuss this issue with their physicians. Since Many alternative forms of therapy can interfere with the modern medicine treatment, it is important that all patients who are using alternative or complimentary forms of treatment convey this information to their physicians.
Past studies have found that prostate cancer patients often begin taking alternative or complementary medicines after receiving their diagnosis. To investigate more specifically, Elkin and his colleagues looked at use of more than 50 different types of complementary or alternative medicines in a group of 2,582 men in a registry of prostate cancer patients.
One third reported using some type of alternative medicine, with 26% using mineral or vitamin supplements, 16% taking herbs, 13% taking antioxidants and 12% taking some type of alternative treatment for "prostate health," such as saw palmetto or lycopene.
Men using alternative medicine tended to have higher incomes, more education, and more advanced cancer at diagnosis. Alternative medicine users also were more likely to have other illnesses. The men who used alternative treatments targeted to prostate health were younger and less likely to be obese.
Jan 23, 2006
Statins And Prostate Cancer (again?)
A new research now shows that men who've been previously diagnosed and treated for prostate cancer and are taking one of these statin drugs like Lipitor or Zocor may have beneficial effects.
The researchers say that statins improve the outcome of prostate cancer treatment with radioactive seed implants (brachytherapy - see January 6th posting to read about seed implants).
This research comes from Wheeling Hospital in West Virginia. Dr. Gregory S. Merrick from and colleagues evaluated the impact of statin therapy on disease progression and long-term survival after in 512 men who had undergone brachytherapy for localized prostate cancer.
At follow-up, prostate-specific antigen (PSA) levels, percentage of positive biopsies, and tumor stage "were significantly lower in the statin than in the nonstatin users," the investigators report in the medical journal Urology.
Survival without recurrence of the disease at 8 years was 97 percent for patients taking statins and 94percent for patients not taking statins, the results indicate.
Higher PSA levels before treatment and being overweight were associated with lower survival rates, the researchers note.
"Since cardiovascular disease is a primary cause of death in men treated for clinically localized prostate cancer, an agent that could potentially benefit both prostate cancer and cardiovascular disease would be of great utility," Merrick commented to Reuters Health.
I would argue that this is an ongoing controversy and no clear final answer regarding the benefits of statin therapy on prostate cancer is available at this time.
Jan 20, 2006
Growth-factor Gene Linked Prostate Cancer
"Our results suggest that inherited variation in IGF1 may play a role in prostate cancer risk," write the scientists in a paper reported in the January 18, 2006, issue of the Journal of the National Cancer Institute.
USC researchers on this research team included: Iona Cheng, who was first author on the paper; Daniel Stram, Ph.D., professor of preventive medicine at the Keck School and the USC/Norris Comprehensive Cancer Center; Malcolm Pike, Ph.D., professor preventive medicine at the Keck School and USC/Norris; and Keck School of Medicine Dean Brian E. Henderson, M.D., who is also a distinguished professor in preventive medicine and neurology and the Kenneth T. Norris Jr. Chair in Cancer Prevention.
Cheng and her colleagues were able to tease out the relevant gene variations using data from the large Multiethnic Cohort study, for which Henderson is co-principal investigator. This population-based cohort study has collected data on more than 215,000 men and women from Los Angeles and Hawaii over the past decade.
From this cohort and information from cancer registries in California and Hawaii, the researchers were able to identify 2320 men who had developed prostate cancer and match them with 2290 men who did not have a prostate cancer diagnosis. This large population, the study's authors noted, provided "substantial [statistical] power to detect modest genetic effects."
Jan 16, 2006
Turmeric Could Halt Prostate Cancer
These reserchers tested turmeric, along with phenethyl isothiocyanate (PEITC), a naturally occurring substance particularly abundant in a group of vegetables that includes watercress, cabbage, winter cress, broccoli, Brussels sprouts, kale, cauliflower, kohlrabi and turnips. They found that this combination was found to be very effective in prevention of prostate cancer. Researchers claim that a combination of PEITC and curcumin could be effective in treating established prostate cancers.
These results are published in the Jan. 15 issue of the journal Cancer Research by Kong and his colleagues at Rutgers' Ernest Mario School of Pharmacy.
The authors noted that in contrast to the high incidence of prostate cancer in the United States, the incidence of this disease is very low in India. This has been attributed to the dietary consumption of large amounts of plant-based foods rich in phytochemicals - nonnutritive plant chemicals that have protective or disease-preventive properties.
Consequently, scientists have been investigating intervention options based on compounds found in edible and medicinal plants. They have had some success, and a majority of patients with prostate cancer are now combining the conventional therapies with these compounds as alternative, supplementary or complementary medications.
For Kong's study, researchers used mice bred so that their immune systems would not reject foreign biological material and injected the mice with cells from human prostate cancer cell lines to grow tumors against which the compounds could be tested.
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The prostate is located just below the bladder and in front of the rectum in male. The tube that carries urine runs through the prostate. The prostate contains cells that make some of the seminal fluid. This fluid protects and nourishes the sperm. Prostate cancer usually starts in the gland cells of the prostate. This kind of cancer is known as adenocarcinoma. Prostate cancer is usually a slow disease, but sometimes it can grow fast and spread quickly to other organs.
Medicineworld.org: Archives of prostate-cancer-blog
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