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July 1, 2006, 9:52 AM CT

Prostatic Radiation Does Not Increase Rectal Cancer Risk

Prostatic Radiation Does Not Increase Rectal Cancer Risk
Men who receive radiation treatment for prostate cancer are not at any appreciable increased risk of developing rectal cancer compared to those not given radiation treatment, as per a new study reported in the July 1, 2006, issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of ASTRO, the American Society for Therapeutic Radiology and Oncology.

This year, 235,000 American men will be diagnosed with prostate cancer. The main ways of dealing with the disease are radiation treatment, surgery and watchful waiting - each of which has its benefits and disadvantages. Scientists have hypothesized that one disadvantage of using radiation to kill the cancer cells in the prostate is that it might also make men more likely to develop cancer in the nearby rectum.

In this study, doctors in Canada evaluated the records of 237,773 men who had prostate cancer. Of them, 33,841 received radiation treatment, 167,607 had their prostate removed surgically and 36,335 received neither therapy. On an initial simple evaluation, doctors found that rectal cancer developed in 243 men who received radiation (0.7 percent), 578 men treated with surgery (0.3 percent), and 227 of the men given neither therapy (0.8 percent). Once doctors had adjusted for the age differences between all the men in the irradiated and non-irradiated groups, they could not find any significant increased risk of rectal cancer in the irradiated men compared to those not given radiation treatment.........

Posted by: Mark      Permalink         Source


June 26, 2006, 10:52 PM CT

Treatment Information Fails To Address Fears

Treatment Information Fails To Address Fears
Men with prostate cancer make emotionally driven therapy decisions influenced by anecdote and misconception rather than consideration of clinical trial evidence, as per a new study. Reported in the August 1, 2006 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society, the study reveals that fear and uncertainty drove initial therapy decisions seeking rapid results, and that there was little interest in seeking second opinions. Furthermore, patient decisions were influenced by misconceptions about disease management options, and men often erroneously applied the anecdotal experiences of others with prostate cancer to their own circumstances, even when the severity of their own disease and available therapy options were significantly different.

While there are several therapy options for men with localized prostate cancer, clinical trials have failed to demonstrate one optimal treatment. Each therapy option has benefits and its own unique and significant adverse side effects. Radical prostatectomy, for example, has only minimal survival benefits compared to even observation, but is associated with complications, such as impotence and urinary incontinence. With no clear-cut medical guidance, patients must assume a greater role in deciding on therapy in the face of disquieting statistics and risk-benefit information.........

Posted by: Mark      Permalink         Source


June 20, 2006, 8:45 PM CT

Predicting Recurrence Of Prostate Cancer

Predicting Recurrence Of Prostate Cancer
new prognostic test can help determine whether a prostate cancer patient will go on to have a recurrence of the disease, even if surrounding lymph nodes initially appear negative for cancer, as per a research studyby University of Southern California researchers.

The test, developed at USC, "appears to be a very powerful test and better than anything else we know of for predicting recurrence," says Richard Cote, professor of pathology and urology at the Keck School of Medicine of USC. Current trials are also using the test to find hidden metastases in lymph nodes and bone marrow for breast and lung cancers.

The study, "Detection of Occult Lymph Node Metastases in Patients with Local Advanced (pT3) Node-Negative Prostate Cancer" appears this week in the Journal of Clinical Oncology.

Prostate cancer is the most common non-skin cancer in America, as per the Prostate Cancer Foundation. One in six American men will be diagnosed with prostate cancer, making men 35 percent more likely to be diagnosed with prostate cancer than women are to be diagnosed with breast cancer.

"Thanks to greater awareness, as well as increased and improved screening, we see men increasingly diagnosed with prostate cancer in its early stages," Cote says. "Most of these patients will do very well and will not require therapy beyond surgery or radiation treatment to cure their disease."........

Posted by: Mark      Permalink         Source


June 19, 2006, 9:24 PM CT

Suggest your News Item To Medicineworld

Suggest your News Item To Medicineworld
As you are aware we are the leading publishers of health news on the web. We publish news items in various forms including numerous blogs and news items. We invite you to participate in our new collection.

We are looking for quality news items that would be interesting to our readers. Now you may suggest the news item from your site to be included at Medicineworld.org. Inclusion of news item at our site get instantaneous attention since the item is illustrated from various blog posts. Addition of pictures to the item adds additional attraction to your news item. Inclusion in the Medicineworld.org site brings quality links and visitors to your site.

If you have an interesting news item related to health, share it with Medicineworld.org and we share it with the world.

Suggest your News Item To Medicineworld........

Posted by: Janet      Permalink


June 1, 2006, 6:59 AM CT

Environmental Estrogens Increases Prostate Cancer Risk

Environmental Estrogens Increases Prostate Cancer Risk
A study in the June 1 issue of Cancer Research presents the first evidence that exposure to low doses of environmental estrogens during development of the prostate gland in the male fetus may result in a predisposition to prostate cancer during the later part of life.

The study, done in an animal model, also demonstrates how the predisposition may arise, and a way to identify those at risk.

Man-made compounds that can mimic the hormone action of estrogens (xenoestrogens) are widespread in the environment. One of these agents is bisphenol A (BPA), used in the manufacture of plastics and epoxy resins. The United States alone produces over 1.6 million pounds of BPA annually. BPA, which can also leach from plastics when heated, turns up in human blood and in placental and fetal tissues in even higher concentrations.

In this study, a research team led by Dr. Gail Prins of the University of Illinois at Chicago and Dr. Shuk-Mei Ho of the University of Cincinnati exposed rats to low doses of estradiol, a natural estrogen, or to BPA during the developmental period corresponding to the second and third trimester of human pregnancy. They found that this early exposure predisposed male rats to premalignant lesions of the prostate in old age.

"Most remarkably, early BPA exposure sensitized the prostate to premalignant lesions brought on by exposure of the adult animal to elevated estradiol," said Prins, professor of urology at UIC and senior author of the study. "This is highly relevant to people, because relative estradiol levels increase in aging men as a result of their increased body fat and declining testosterone levels."........

Posted by: Mark      Permalink         Source


April 18, 2006, 11:39 PM CT

Using PSA Endpoints For Prostate Cancer Research

Using PSA Endpoints For Prostate Cancer Research
A new study from Columbia University Medical Center scientists at NewYork-Presbyterian Hospital/Columbia, who are members of the Southwest Oncology Group (SWOG), suggests that certain changes in prostate-specific antigen (PSA) levels may serve as surrogate endpoints for prostate cancer survival. Scientists looking to speed up the process of clinical trials have suggested that these biomarkers could be used to measure therapy efficacy.

Currently, the U.S. Food and Drug Administration accepts only survival as an endpoint of measure. Survival as a primary endpoint was used in phase III studies of novel chemotherapeutic drugs for men with androgen-independent prostate.

Daniel P. Petrylak, M.D., associate professor of medicine at Columbia University College of Physicians & Surgeons and director of the genitourinary oncology program at NewYork-Presbyterian/Columbia, together with his research team, retrospectively analyzed results of 551 men with prostate cancer treated in the Southwest Oncology Group Protocol S9916. By reviewing the clinical trial, it was noted that there were several different changes in PSA levels, which could possibly serve as surrogate endpoints for survival.

The authors observed that the risk of death, in men whose serum PSA levels declined by at least 30 percent in the first three months of therapy, was reduced more than 50 percent. Findings are reported in the Journal of the National Cancer Institute (April 19, 2006 issue).........

Posted by: Mark      Permalink         Source


April 16, 2006, 8:13 PM CT

More Research Needed Into Cholesterol Prostate Cancer Link

More Research Needed Into Cholesterol Prostate Cancer Link
Cancer Research UK has called for further research after a study claimed to have identified a link between cholesterol intake and prostate cancer risk.

The research, by the Istituto di Ricerche Farmacologiche Mario Negri in Italy and reported in the annals of Oncology, used questionnaires to assess men?s medical histories, including their prior cholesterol levels.

"This study is based on questionnaires rather than directly measured cholesterol levels, so follow-up research is needed before the firm conclusion can be drawn that high cholesterol levels are directly linked to prostate cancer risk," said Henry Scowcroft of Cancer Research UK.

"There is some evidence to suggest that men who eat a high fat diet have a greater risk of prostate cancer, but we do not know for sure whether high levels of fats in the bloodstream actually cause prostate cancer.

"It may be that men who lead a typical western lifestyle are exposed to other factors that could increase their risk," he added.

Some prior research has suggested a link between prostate cancer and cholesterol levels, but firm evidence has remained elusive.

Prostate cancer is the most common form of the disease among men in the UK, with 30,100 new cases diagnosed every year.........

Posted by: Mark      Permalink         Source


April 12, 2006, 5:51 PM CT

Looking For Participant For An Online Survey Of Cancer Blogs

Looking For Participant For An Online Survey Of Cancer Blogs
Survey

Deborah S. Chung, Ph.D. who is Assistant Professor at University of Kentucky School of Journalism and Telecommunications has contacted me about an online survey for cancer patients. This is a study about cancer blog use by cancer patients.

The purpose of this study is to describe characteristics of cancer blog users and their motivations for visiting cancer blogs. In addition, this study hopes to assess behavioral changes after using cancer blogs and to draw associations between everyday use of media and use of cancer blogs.

This study will help cancer information seekers and healthcare providers alike understand how blogs as a new communication tool may potentially help cancer patients seek information and/or communication.

The information collected form this survey will be accessible only to the researchers. No personally identifiable information will be collected, and information will be presented in aggregate form. The survey will be collected on a server with SSL (Secure Sockets Layer) capabilities, which is one of the best providers of Internet security available, but there is always a risk that a third party may intercept the survey answers.

There are no foreseeable risks associated to this study. However, if you feel uncomfortable answering the survey questions, you may choose to skip a question or withdraw from the study at any time.........

Posted by: Sherin      Permalink         Source


April 7, 2006, 6:59 AM CT

Pain Medications Prevent Cancer

Pain Medications Prevent Cancer
Results results from a new, five-year study is showing that regular use this popular group of prescription pain relievers may reduce the risk of breast cancer by up to 71 percent. In addition, these drugs may also benefit in the prevention of prostate, colon and lung cancers.

These study findings were reported in the recent annual meeting of the American Association for Cancer Research in Washington, D.C. The researchers have found significant chemopreventive effects against breast cancer with the regular use of Cox-2 inhibitors and other non-steroidal anti-inflammatory drugs. The study was conducted by Dr. Randall Harris, professor and director of the Center for Molecular Epidemiology and Environmental Health in The Ohio State University College of Medicine.

Dr. Randall Harris and colleagues conducted a large case-control study of Cox-2 inhibitors and studied their impact upon the four leading types of cancer in the United States: breast, lung, prostate and colon cancer. COX-2 inhibitors are non-steroidal, anti-inflammatory drugs that specifically block the COX-2 enzyme pathway that is often activated in inflammation, cancer, heart disease and other disorders.

Harris and his colleagues studied the use of celecoxib (Celebrex), rofecoxib (Vioxx), regular aspirin, low-dose aspirin, ibuprofen and acetaminophen among 323 women with breast cancer from 1999-2004.........

Posted by: Janet      Permalink         Source


April 4, 2006, 0:26 AM CT

Gene Rearrangement Involved In Prostate Cancer

Gene Rearrangement Involved In Prostate Cancer
Scientists at the University of Michigan Medical School have identified a third gene involved in prostate cancer, expanding their groundbreaking announcement, published last October in Science, that the majority of prostate cancers carry a malignancy-inducing fusion of genes never before seen in solid tumors.

The new findings are reported in the April 1 issue of Cancer Research. Since prostate cancer is a cancer of the epithelial cells lining organs, lead researcher Arul Chinnaiyan and colleagues believe it likely that other gene re-arrangements may be responsible for other cancers of epithelial tissue, including breast, colon and lung.

Scott Tomlins, a MD/PhD graduate student in Dr. Chinnaiyan's laboratory and the lead author of the Science paper, presented the study Tuesday, April 4, at Experimental Biology 2006 in San Francisco. The presentation was part of the scientific program of the American Society for Investigative Pathology (ASIP) held at Experimental Biology, and Mr. Tomlins is the winner of the 2006 ASIP Experimental Pathologist-in-Training Award.

The ETV4 gene is a member of the same family as the two other genes, ETV1 and ERG, reported earlier. All three are ETS genes, a group of approximately 30 genes that encode related transcription factors. Like other family members, ETV4 has a role in normal cell division but is uncommonly active, or overly expressive, only when it becomes fused with other genes on different chromosomes. Using the same technology as the earlier study, the researchers were able to demonstrate that the ETV4 gene had become fused with another prostate cancer gene on another chromosome.........

Posted by: Mark      Permalink         Source



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Prostate cancer
The prostate is located just below the bladder and in front of the rectum in male. The tube that carries urine runs through the prostate. The prostate contains cells that make some of the seminal fluid. This fluid protects and nourishes the sperm. Prostate cancer usually starts in the gland cells of the prostate. This kind of cancer is known as adenocarcinoma. Prostate cancer is usually a slow disease, but sometimes it can grow fast and spread quickly to other organs.

Medicineworld.org: Archives of prostate-cancer-blog

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