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Medicineworld.org: HIV-infected postmenopausal women

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HIV-infected postmenopausal women




As per a newly released study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM), postmenopausal HIV-infected women have a high prevalence of low bone mineral density and high bone turnover placing them at high risk for future bone fractures.



HIV-infected postmenopausal women

"As HIV-infected individuals live longer with potent antiretroviral treatment (ART), metabolic complications such as low bone density and osteoporosis are increasingly recognized," said Michael Yin, MD of Columbia University Medical Center in New York and main author of the study. "Eventhough numbers of HIV-infected postmenopausal women are increasing and postmenopausal women are at highest risk for osteoporotic fractures, few studies have reviewed skeletal status in this group. We hypothesized that postmenopausal women might be especially vulnerable to the adverse effects of HIV infection or ART on the skeleton and our results indicate that this may indeed be the case".

To test their hypothesis, Yin and colleagues initiated a longitudinal study to assess bone health in 92 HIV-positive and 95 HIV-negative postmenopausal women. Bone mineral density of the lumbar spine, femoral neck and hip as well as body composition were measured by dual x-ray absorptiometry (DXA). Scientists observed that HIV-positive postmenopausal women had lower bone mineral density at both the spine and hip than HIV-negative postmenopausal women.

"HIV infection was independently linked to lower bone mineral density after adjusting for body mass index (BMI) and traditional osteoporosis risk factors," said Yin. "While the reason for HIV-associated bone loss remains unclear, it appears to be correlation to increased levels of cytokines (proteins produced by cells that aid communication between cells), direct effects of antiretrovirals on bone cells or hormonal/nutritional deficiencies that are common in HIV".

"Estrogen protects against the effect of cytokines on bone resorption," said Yin. "Therefore, as HIV-positive women become estrogen deficient during menopause, they appears to be at higher risk for accelerated bone loss and fracture".


Posted by: Mark    Source




Did you know?
As per a newly released study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM), postmenopausal HIV-infected women have a high prevalence of low bone mineral density and high bone turnover placing them at high risk for future bone fractures.

Medicineworld.org: HIV-infected postmenopausal women

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