MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

Medicineworld.org: Bacteria possible cause of preterm births

Back to obgyn news Blogs list Cancer blog  


Subscribe To Obgyn News RSS Feed  RSS content feed What is RSS feed?

Bacteria possible cause of preterm births




The type of bacteria that colonize the placenta during pregnancy could be linked to preterm birth and other developmental problems in newborns as per research reported in the current issue of the online journal mBio�.

"The fetal inflammatory response appears to contribute to the onset of preterm labor, fetal injury and complications, underlying lifetime health challenges facing these children," say the scientists from Harvard Medical School, Brigham and Women's Hospital and Children's Hospital of Boston. "Our data suggest that placental colonization by specific groups of organisms can increase or decrease the risk of a systemic inflammatory condition".



Bacteria possible cause of preterm births

Preterm birth occurs in nearly a half million pregnancies in the United States alone. Despite improved care, preterm and particularly extremely low-gestational-age newborns continue to be at a considerably higher risk of morbidity, mortality and developmental problems. Much of this risk is attributable to imbalanced inflammatory responses of the fetus and newborn.

The systemic fetal inflammatory response to intrauterine exposures, particularly intrauterine infections, is regarded as an important contributor to the onset and often lifelong consequences of preterm labor, fetal injury and early organ damage. Approximately half of all placentas delivered before the second trimester and 41% of those delivered by Caesarean section harbor microorganisms detectable by culture techniques.

In order to better understand what role, these microorganisms could play in the extremely preterm inflammatory response the scientists analyzed protein biomarkers in dry blood spots obtained from 527 newborns delivered by Caesarean section and cultured and identified the bacteria from their respective placentas.

Placentas colonized primarily by microorganisms usually linked to the condition know as bacterial vaginosis (BV) were found to be linked to elevated levels of proinflammatory protein in newborns. In contrast, colonization by Lactobacillus species of bacteria (often found in decreased concentrations during BV) were linked to lower levels of proinflammatory proteins.

"Our study supports the concept that the placental colonization with vaginal microorganisms can induce a systemic inflammatory response in the fetus and newborn and that the dominating molecular feature of this response can be dependent on the type of bacteria," says Andrew Onderdonk of Harvard Medical School and Brigham and Women's Hospital, one of the authors of the study. "Our data suggest that the targeting of placental colonization by specific drugs or probiotics during early pregnancy may hold promise for preventing not only preterm birth but also the devastating and far-reaching inflammatory consequences in premature newborns".


Posted by: Emily    Source




Did you know?
The type of bacteria that colonize the placenta during pregnancy could be linked to preterm birth and other developmental problems in newborns as per research reported in the current issue of the online journal mBio�. "The fetal inflammatory response appears to contribute to the onset of preterm labor, fetal injury and complications, underlying lifetime health challenges facing these children," say the scientists from Harvard Medical School, Brigham and Women's Hospital and Children's Hospital of Boston. "Our data suggest that placental colonization by specific groups of organisms can increase or decrease the risk of a systemic inflammatory condition".

Medicineworld.org: Bacteria possible cause of preterm births

Asthma| Hypertension| Medicine Main| Diab french| Diabetes drug info| DruginfoFrench| Type2 diabetes| Create a dust free bedroom| Allergy statistics| Cancer terms| History of cancer| Imaging techniques| Cancer Main| Bladder cancer news| Cervix cancer news| Colon cancer news| Esophageal cancer news| Gastric cancer news| Health news| Lung cancer news| Breast cancer news| Ovarian cancer news| Cancer news|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.