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Medicineworld.org: CPAP therapy reduces fatigue

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CPAP therapy reduces fatigue




Patients with obstructive sleep apnea often report that they feel like "a new person" after beginning therapy with continuous positive airway pressure treatment. A newly released study in the Jan. 1 issue of the journal SLEEP provides objective evidence to support these anecdotal reports, showing that three weeks of CPAP treatment significantly reduced fatigue and increased energy in patients with OSA.



 CPAP therapy reduces fatigue

Results of the randomized controlled trial show that CPAP treatment significantly reduced self-reported, mean fatigue scores on two independent measures: from 8.76 at baseline to -0.10 post-treatment on the Multidimensional Fatigue Symptom Inventory � Short Form; and from 7.17 at baseline to 4.03 post-treatment on the fatigue-inertia subscale of the Profile of Mood States � Short Form. These results indicate that participants were no longer suffering from clinically significant levels of fatigue after the three-week intervention period.

Self-reported energy levels also increased after three weeks of CPAP treatment, with the mean score on the vigor-activity subscale of the Profile of Mood States � Short Form increasing significantly from 14.28 at baseline to 16.52 post-treatment. Significant changes in fatigue and energy were not observed in participants who received placebo CPAP.

"This was one of the first double-blind studies of the effects of CPAP on fatigue," said main author Lianne Tomfohr, graduate research assistant in the joint doctoral program at San Diego State University and the University of California, San Diego. "These results are important, as they highlight that patients who comply with CPAP treatment can find relief from fatigue and experience increases in energy and vigor after a relatively short therapy period".

Further analysis observed that CPAP appeared to be particularly beneficial for participants who were excessively fatigued or sleepy before therapy. CPAP treatment significantly reduced self-reported daytime sleepiness in this group, with their mean score on the Epworth Sleepiness Scale dropping from 13.0 at baseline to 8.9 post-treatment.

As per the American Academy of Sleep Medicine, OSA is a common sleep-related breathing disorder that affects at least two to four percent of the adult population. OSA occurs when the muscles relax during sleep, causing soft tissue in the back of the throat to collapse and block the upper airway. Most people with OSA snore loudly and frequently, and they often experience fatigue and excessive daytime sleepiness.

The therapy of choice for OSA is CPAP treatment, which provides a steady stream of air through a mask that is worn during sleep. This airflow keeps the airway open to prevent pauses in breathing and restore normal oxygen levels.

Tomfohr and a team of UCSD scientists studied 59 adults with a mean age of 48 years. Overnight polysomnography in a sleep lab confirmed that each participant had OSA, which was defined as having an apnea-hypopnea index (AHI) of 10 or more partial reductions (hypopneas) and complete pauses (apneas) in breathing per hour of sleep.

Participants were randomly assigned to receive either therapeutic CPAP or placebo CPAP, and they returned to the sleep lab for a night of either CPAP titration or mock titration. Participants were trained on the use of the equipment and instructed to use it at home each night for three weeks. Questionnaire data were obtained previous to study randomization and after the three-week intervention period.

As per the authors, the mechanisms that underlie the observed changes in fatigue are unclear. They speculate that CPAP may impact fatigue in patients with OSA by reducing inflammation, noting that increases in inflammatory markers in OSA patients have been correlation to elevated fatigue.


Posted by: Daniel    Source




Did you know?
Patients with obstructive sleep apnea often report that they feel like "a new person" after beginning therapy with continuous positive airway pressure treatment. A newly released study in the Jan. 1 issue of the journal SLEEP provides objective evidence to support these anecdotal reports, showing that three weeks of CPAP treatment significantly reduced fatigue and increased energy in patients with OSA.

Medicineworld.org: CPAP therapy reduces fatigue

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