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Medicineworld.org: Antioxidants against the flu virus

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Antioxidants against the flu virus




As the nation copes with a shortage of vaccines for H1N1 influenza, a team of Alabama scientists have raised hopes that they have found an Achilles' heel for all strains of the fluantioxidants. In an article appearing in the November 2009 print issue of the FASEB Journal (http://www.fasebj.org) they show that antioxidantsthe same substances found in plant-based foodsmight hold the key in preventing the flu virus from wreaking havoc on our lungs.

"The recent outbreak of H1N1 influenza and the rapid spread of this strain across the world highlights the need to better understand how this virus damages the lungs and to find new therapys," said Sadis Matalon, co-author of the study. "Additionally, our research shows that antioxidants may prove beneficial in the therapy of flu".



Antioxidants against the flu virus

Matalon and his colleagues showed that the flu virus damages our lungs through its "M2 protein," which attacks the cells that line the inner surfaces of our lungs (epithelial cells). Specifically, the M2 protein disrupts lung epithelial cells' ability to remove liquid from inside of our lungs, setting the stage for pneumonia and other lung problems. The scientists made this discovery by conducting three sets of experiments using the M2 protein and the lung protein they damage. First, frog eggs were injected with the lung protein alone to measure its function. Second, scientists injected frog eggs with both the M2 protein and the lung protein and observed that the function of the lung protein was significantly decreased. Using molecular biology techniques, researchers isolated the segment of the M2 protein responsible for the damage to the lung protein. Then they demonstrated that without this segment, the protein was unable to cause damage. Third, the full M2 protein (with the "offending" segment intact) and the lung protein were then re-injected into the frog eggs along with drugs known to remove oxidants. This too prevented the M2 protein from causing damage to the lung protein. These experiments were repeated using cells from human lungs with exactly the same results.

"Eventhough vaccines will remain the first line of intervention against the flu for a long time to come, this study opens the door for entirely new therapys geared toward stopping the virus after you're sick," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "and as Thanksgiving approaches, this discovery is another reason to drink red wine to your health."


Posted by: Mark    Source




Did you know?
As the nation copes with a shortage of vaccines for H1N1 influenza, a team of Alabama scientists have raised hopes that they have found an Achilles' heel for all strains of the fluantioxidants. In an article appearing in the November 2009 print issue of the FASEB Journal (http://www.fasebj.org) they show that antioxidantsthe same substances found in plant-based foodsmight hold the key in preventing the flu virus from wreaking havoc on our lungs.

Medicineworld.org: Antioxidants against the flu virus

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