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Overweight, breathing and sleep disorders




Overweight individuals are not just at greater risk of having sleep-disordered-breathing (SDB), they are also likely to suffer greater consequences, as per new research.

As per the study, to be reported in the October 15 issue of the American Journal of Respiratory and Critical Care Medicine, an official publication of the American Thoracic Society, excess weight increased the severity of oxygen desaturation in the blood of individuals with SDB during and after apneas and hypopneas.



Overweight, breathing and sleep disorders

"We knew that excess body weight is strongly correlation to more frequent breathing eventsapneas and hypopneasin persons with SDB," said main author Paul E. Peppard, Ph.D., assistant professor of population health sciences at the University of Wisconsin-Madison. "In this study, we wanted to go a step further and measure how much the excess weight contributes to the severity of individual breathing events".

Dr. Peppard and his colleagues recruited 750 adults from the Wisconsin Sleep Cohort study, an ongoing epidemiological investigation into the natural history of SDB, to have their breathing, blood-oxygen levels and sleep analyzed. Participants were also reviewed on several measures of physiquebody mass index (BMI), neck -circumference and waist-to-hip ratio.

Among the participants in the overnight study, 40 percent of whom were obese, there were more than 37,000 SDB events. The scientists observed that many factors influenced the severity of blood oxygen desaturation linked to these events, including age, gender, body position and sleep phase (REM or non-REM sleep). However, even after these other factors were accounted for, the scientists observed that BMI predicted the degree to which the body's tissues were "starved" of oxygen during apneas and hypopneas. In fact, each 10-point increase in BMI predicted a 10 percent increase in the severity of oxygen depletion linked to SDB events.

"This means that if, for example, a six-foot tall, 160-pound 45-year-old man (BMI= 22), had an apnea that produced a six-percent reduction in oxygen saturation, then a man with the same characteristics who weighed 235 pounds (BMI=32) would be expected to have a 6.6 percent reduction in blood oxygen saturation during a similar event," explained Dr. Peppard. "This increased risk of more severe oxygen desaturation is not just linked to clinical obesityany increase in weight above a BMI of approximately 25 appears to increase the risk and severity of SDB," he noted.

Mary Morrell, Ph.D., from the Imperial College London, who collaborated on the study, pointed out that of all the factors found to influence the severity of oxygen desaturation, being overweight is one of the only factors that is modifiable, suggesting it as a logical target for SDB interventions.

"These results reinforce the importance of excess weight as a risk factor for the development, progression and severity of SDB," said Dr. Peppard. "Clinicians should consider the possibility that especially overweight patients might be experiencing severer consequences of SDB even if they have the same number of breathing events as less overweight patients".

While these findings represent an important step in understanding the consequences and risk factors linked to excess weight and SDB, Dr. Peppard emphasizes that more research is mandatory to fully understand the issue. "Ongoing studies are looking into how, and to what degree, repeated oxygen desaturations produce poor clinical outcomes," he said. "We also need to assess the impact of the obesity epidemic on sleep apnea prevalence and severity in the general population. Our research groupthe Wisconsin Sleep Cohort Studyis presently working on the latter question. Multiple research groups spanning basic science to population-level sciences are working on the former".


Posted by: JoAnn    Source




Did you know?
Overweight individuals are not just at greater risk of having sleep-disordered-breathing (SDB), they are also likely to suffer greater consequences, as per new research. As per the study, to be reported in the October 15 issue of the American Journal of Respiratory and Critical Care Medicine, an official publication of the American Thoracic Society, excess weight increased the severity of oxygen desaturation in the blood of individuals with SDB during and after apneas and hypopneas.

Medicineworld.org: Overweight, breathing and sleep disorders

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