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Medicineworld.org: Childhood adversity may lead to unhealthy stress

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Childhood adversity may lead to unhealthy stress




Seemingly healthy adults, if they were abused or neglected during childhood, may suffer physiological consequences decades later. In research published online last week by the journal Neuropsychopharmacology, a team led by psychiatry experts at Brown University and Butler Hospital observed that healthy adults who reported being mistreated as kids appear to have an elevated inflammatory response to stress in comparison to adults who had happier childhoods.



Childhood adversity may lead to unhealthy stress
Linda Carpenter
Associate Professor of Psychiatry and Human Behavior

Main author Linda Carpenter, associate professor of psychiatry and human behavior, said that previous research has revealed preliminary associations between inflammatory markers, (such as cytokines or proteins released in the bloodstream such as interleuken-6) and depression and anxiety disorders, so this new finding could ultimately improve doctors' understanding of how stressors in childhood shape the risk people face for developing those conditions during the later part of life.

"Animal models have given us some signals about how the functioning of an organism's stress response system can run amok for the rest its life as a result of some of the earliest environment exposures - adverse ones in particular," said Carpenter, who also treats patients as chief of the mood disorders practice at Butler. "This is one of many studies we've been doing with generally healthy adults, looking at the effects of adverse early environment and how it might create a biological abnormality that could predispose somebody to future depression or another medical disorders".

A study in 2006 at Emory University had shown that men who were mistreated as kids and were now struggling with symptoms of depression as adults had an elevated inflammatory response to stress, Carpenter said. The goal of her team in this pilot study was to find out whether the same is true of adults who endured early life adversity, but are not experiencing psychiatric disorders like depression. The results supported the idea that people who struggled with childhood abuse and neglect have exaggerated immune system reactions during the later part of life, Carpenter said, perhaps in dicating a trajectory toward future health challenges.

Stress test.

To conduct the research, the team recruited 69 adults, ranging in age from their late teens to early 60s. After administering a battery of tests to ensure that the subjects were psychiatrically healthy and not taking any medicines or drugs that would bias the results, the team surveyed them extensively about their childhood experiences. Of the group, 19 reported moderate to severe neglect or abuse.

To measure each group's inflammatory response to stress, the scientists then asked them to undergo a laboratory role-play called the Trier Social Stress Test, in which they had to appear before a panel of "judges" and both speak about their qualifications for their job and then count backward from a number by 13s. All the while, the scientists were measuring various vital signs and collecting blood samples.

Among the subjects who reported adverse childhood experiences, the concentrations of interleukin-6 in their blood were always elevated above those of the control group, and the gap widened considerably as the subject recovered from the psychological stress during several hours after the role-play.

Advancing disease understanding.

Further research is necessary - for instance, expanding this small study to incorporate a larger sample size, Carpenter said. That, combined with more work exploring the correlation between immune system function and depression, could eventually lead to a blood test that would be used to assess a patient's risk for developing depression or other medical disorders. It might also guide the choice of therapys or prevention measures.

"We're still not at a point,where we can say to healthy people 'Go get your stress-test cytokine profile done' as a tool to prevent, diagnose, or treat medical disorders," she said. "But what's clear is that a life of excessive stress-induced inflammatory chemicals in your bloodstream is unlikely to be a good thing".

In the future, the way to help some patients, Carpenter added, might be in finding ways to ratchet down that inflammatory response to stress.

In addition to Carpenter, other authors were Lawrence Price, professor of psychiatry and human behavior and clinical and research director at Butler Hospital; Audrey R. Tyrka, assistant professor of psychiatry and human behavior, based at Butler hospital; Brown graduate student Cyrena Gawuga; Butler researcher Janet Lee; and Yale University researcher George Anderson.


Posted by: JoAnn    Source




Did you know?
Seemingly healthy adults, if they were abused or neglected during childhood, may suffer physiological consequences decades later. In research published online last week by the journal Neuropsychopharmacology, a team led by psychiatry experts at Brown University and Butler Hospital observed that healthy adults who reported being mistreated as kids appear to have an elevated inflammatory response to stress in comparison to adults who had happier childhoods.

Medicineworld.org: Childhood adversity may lead to unhealthy stress

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