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Medicineworld.org: Ginkgo biloba may not work

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Ginkgo biloba may not work




Elderly adults who used the herbal supplement Ginkgo biloba for several years did not have a slower rate of cognitive decline in comparison to adults who received placebo, as per a research studyin the December 23/30 issue of JAMA
"Ginkgo biloba is marketed widely and used with the hope of improving, preventing, or delaying cognitive impairment linked to aging and neurodegenerative disorders such as Alzheimer disease," the authors write. "Indeed, in the United States and especially in Europe, G biloba is perhaps the most widely used herbal therapy consumed specifically to prevent age-related cognitive decline." However, evidence from large clinical trials regarding its effect on long-term cognitive functioning is lacking.



Ginkgo biloba may not work
Ginkgo leaf

Beth E. Snitz, Ph.D., of the University of Pittsburgh, and his colleagues analyzed outcomes from the Ginkgo Assessment of Memory (GEM) study to determine if G biloba slowed the rate of cognitive decline in elderly adults who had normal cognition or mild cognitive impairment (MCI) at the beginning of the study. The GEM study previously observed that G biloba was not effective in reducing the occurence rate of Alzheimer dementia or dementia overall. The randomized, double-blind, placebo-controlled clinical trial included 3,069 community-dwelling participants, ages 72 to 96 years, who received a twice-daily dose of 120-mg extract of G biloba (n = 1,545) or identical-appearing placebo (n = 1,524). The study was conducted at six academic medical centers in the United States between 2000 and 2008, with a median (midpoint) follow-up of 6.1 years. Change in cognition was assessed by various tests and measures.

In this study, the largest randomized controlled trial of G biloba to report on outcomes to date, the scientists found no evidence for an effect of G biloba on global cognitive change and no evidence of effect on specific cognitive domains of memory, language, attention, visuospatial abilities and executive functions. They also found no evidence for differences in therapy effects by age, sex, race, education or baseline cognitive status (MCI vs. normal cognition).

"In sum, we find no evidence that G biloba slows the rate of cognitive decline in elderly adults. These findings are consistent with prior smaller studies examining prevention of decline and facilitation of cognitive performance and with the 2009 Cochrane review of G biloba for dementia and cognitive impairment".


Posted by: Janet    Source




Did you know?
Elderly adults who used the herbal supplement Ginkgo biloba for several years did not have a slower rate of cognitive decline in comparison to adults who received placebo, as per a research studyin the December 23/30 issue of JAMA "Ginkgo biloba is marketed widely and used with the hope of improving, preventing, or delaying cognitive impairment linked to aging and neurodegenerative disorders such as Alzheimer disease," the authors write. "Indeed, in the United States and especially in Europe, G biloba is perhaps the most widely used herbal therapy consumed specifically to prevent age-related cognitive decline." However, evidence from large clinical trials regarding its effect on long-term cognitive functioning is lacking.

Medicineworld.org: Ginkgo biloba may not work

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