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Medicineworld.org: Green tea blocks benefits of cancer drug

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Green tea blocks benefits of cancer drug




Contrary to popular assumptions about the health benefits of green tea, scientists at the University of Southern California (USC) have observed that the widely used supplement renders a cancer drug used to treat multiple myeloma and mantle cell lymphoma completely ineffective in treating cancer.

The study, which observed that a component of green tea extract (GTE) called EGCG destroys any anticancer activity of the drug Velcade in tumor-bearing mice, will be published in a future print edition of the journal, Blood It is now available online at the journal's pre-publication First Edition website.



Green tea blocks benefits of cancer drug

"Our finding that GTE or EGCG blocked the therapeutic action of Velcade was completely unexpected," says main author Axel H. Schnthal, PhD, associate professor in the Department of Microbiology and Immunology at the Keck School of Medicine of USC. "Our hypothesis was that GTE or EGCG would enhance the anti-tumor effects of Velcade, and that a combination of GTE with Velcade (or EGCG with Velcade) would turn out to be a superior cancer therapy as in comparison to therapy with Velcade alone."

Herbal remedies, including green tea, have become a popular remedy for cancer patients dealing with side effects of chemotherapy. However, these supplements are unregulated and, for most, their beneficial and/or detrimental effects have not been qualified through research.

Using preclinical models and tumor-bearing mice, the scientists observed that the uncommonly effective blockage of Velcade's therapeutic activity was based on the chemical interaction between molecules. The EGCG molecule and the Velcade molecule were able to form chemical bonds, meaning that the Velcade molecule could no longer bind to its intended target inside the tumor cells.

Clincal trials to verify these results in humans would be highly unethical to conduct, because of the predictably unfavorable outcome. Nevertheless, the scientists expect the results of the study to be applicable to cancer patients.

"The most immediate conclusion from our study is the strong advice that patients undergoing cancer treatment with Velcade must avoid green tea, and in particular all of its concentrated products that are freely available from health food stores," says Schnthal. "It is important to spread this message to health care providers who administer Velcade to patients."

Schnthal points out that for patients on Velcade, supplementing with green tea products should reduce the burden of harsh side effectswhich might be attractive to the patient, but comes at a high cost.

"Essentially, in addition to not being able to attack tumor cells, Velcade would be unable to cause side effects either," he says. "As a result, the patient would feel a lot better and conclude that the consumption of GTE helped cope with side effectswhile in reality, Velcade simply wasn't active in the first place".

The research findings are part of a larger project run by the team called "Yin-Yang Properties of Green Tea Extract in Combination Cancer Chemotherapy: From Encouragingly Beneficial to Dangerously Detrimental".

"Obviously, the combination of GTE or EGCG with Velcade is an example of 'dangerously detrimental,' "Schnthal says. "But we are also studying another well-established chemotherapeutic drug, where the inclusion of EGCG appears to yield an 'encouragingly beneficial' outcome, which is more in line with our original expectation that GTE should be beneficial, not detrimental".


Posted by: Janet    Source




Did you know?
Contrary to popular assumptions about the health benefits of green tea, scientists at the University of Southern California (USC) have observed that the widely used supplement renders a cancer drug used to treat multiple myeloma and mantle cell lymphoma completely ineffective in treating cancer.

Medicineworld.org: Green tea blocks benefits of cancer drug

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