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Medicineworld.org: Hepatitis C drug may revolutionize treatment

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Hepatitis C drug may revolutionize treatment




The drug boceprevir helps cure hard-to-treat hepatitis C, says Saint Louis University investigator Bruce R. Bacon, M.D., author of the March 31 New England Journal (NEJM) article detailing the study's findings. The results, which were first reported at the 61st annual meeting of the American Association for the Study of Liver Disease's last November, offer a brighter outlook for patients who have not responded to standard therapy.

Bacon, who is professor of internal medicine at Saint Louis University School of Medicine and co-principal investigator of the HCV RESPOND-2 study, studied the protease inhibitor boceprevir and observed that it significantly increased the number of patients whose blood had undetectable levels of the virus.



Hepatitis C drug may revolutionize treatment

"These findings are particularly significant for patients who don't respond to initial therapy," said Bacon. "When the hepatitis C virus is not eliminated, debilitating fatigue and more serious problems can follow".

Hepatitis C is caused by a virus that is transmitted by contact with blood. The infection may initially be asymptomatic, but for patients who develop chronic hepatitis C infection, inflammation of the liver may develop, leading to fibrosis and cirrhosis (scarring of the liver), as well as other complications including liver cancer and death.

The prognosis varies for patients with chronic hepatitis C. With the current standard treatment, about half fully recover after an initial course of peginterferon and ribavirin anti-viral treatment that may last from six months to a year.

The remaining patients, known as non-responders, may improve with initial therapy but the virus is not eliminated, or may not respond to therapy at all. For this group, the only current option is to re-treat patients with the same or similar drugs, which increases the likelihood of severe therapy side-effects. In addition, scientists have observed that the success of therapy depends on the major strain, or genotype, of hepatitis C that a patient has.

The HCV RESPOND-2 study looked at 403 patients with chronic hepatitis C infections with genotype one, the most difficult strain of the virus to treat, who still had significant levels of the virus after being treated with peginterferon and ribavirin, the standard hepatitis C therapy.

"These results are very exciting," Bacon said. "In this study, boceprevir helped cure significantly more patients in 36 weeks of treatment than did therapy with peginterferon and ribavirin alone".

A second study, HCV SPRINT-2, examined patients with hepatitis C with genotype one who had still not been treated with the standard therapy. They, too, responded well to the drug.

Bacon calls the progress made in treating hepatitis C remarkable.

"We've gone from the discovery of the virus in 1989 to where we are now, 22 years later, when we have the ability to cure a great majority of those with hepatitis C," Bacon said. "It's a true success story".

"Drugs like boceprevir are going to revolutionize care of those with hepatitis C".


Posted by: Mark    Source




Did you know?
The drug boceprevir helps cure hard-to-treat hepatitis C, says Saint Louis University investigator Bruce R. Bacon, M.D., author of the March 31 New England Journal (NEJM) article detailing the study's findings. The results, which were first reported at the 61st annual meeting of the American Association for the Study of Liver Disease's last November, offer a brighter outlook for patients who have not responded to standard therapy.

Medicineworld.org: Hepatitis C drug may revolutionize treatment

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