MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

Medicineworld.org: How does lithium work in bipolar disease?

Back to psychology news Blogs list Cancer blog  


Subscribe To Psychology News RSS Feed  RSS content feed What is RSS feed?

How does lithium work in bipolar disease?




Lithium has been established for more than 50 years as one of the most effective therapys for bipolar mood disorder.

However, researchers have never been entirely sure exactly how it operates in the human brain.

Now, new research from Cardiff University researchers suggests a mechanism for how Lithium works, opening the door for potentially more effective therapys.

Laboratory tests on cells have shown that Lithium affects a molecule called PIP3 that is important in controlling brain cell signalling. Lithium suppresses the production of inositol, a simple sugar from which PIP3 is made.



How does lithium work in bipolar disease?

Lithium inhibits inositol monophosphatase (IMPase) an enzyme mandatory for making inositol. Importantly, this research shows that increasing the amount of IMPase causes higher levels of PIP3. This can then be reduced by lithium therapy.

High levels of IMPA2, a gene for a variant of IMPase, has previously been associated with bipolar mood disorder. This new result suggests that Lithium could counteract the changes in IMPA2.

Professor Adrian Harwood of Cardiff School of Biosciences, who led the research, said: "We still cannot say definitively how Lithium can help stabilise bipolar disorder. However, our research does suggest a possible pathway for its operation. By better understanding Lithium, we can learn about the genetics of bipolar disorder and develop more potent and selective drugs.

"Further, altered PIP3 signalling is associated with other disorders, including epilepsy and autism, so this well established drug could be used to treat other conditions. Research into Lithium could become very important over the next few years".

Lithium is currently under clinical trial for the therapy of neurogenerative disorder amyotrophic lateral sclerosis (ALS).

The research, funded by the Wellcome Trust, is reported in the journal Disease Models and Mechanisms


Posted by: JoAnn    Source




Did you know?
Lithium has been established for more than 50 years as one of the most effective therapys for bipolar mood disorder. However, researchers have never been entirely sure exactly how it operates in the human brain. Now, new research from Cardiff University researchers suggests a mechanism for how Lithium works, opening the door for potentially more effective therapys.

Medicineworld.org: How does lithium work in bipolar disease?

Acute bacterial meningitis| Alzheimer's disease| Carpal tunnel syndrome| Cerebral aneurysms| Cerebral palsy| Chronic fatigue syndrome| Cluster headache| Dementia| Epilepsy seizure disorders| Febrile seizures| Guillain barre syndrome| Head injury| Hydrocephalus| Neurology| Insomnia| Low backache| Mental retardation| Migraine headaches| Multiple sclerosis| Myasthenia gravis| Neurological manifestations of aids| Parkinsonism parkinson's disease| Personality disorders| Sleep disorders insomnia| Syncope| Trigeminal neuralgia| Vertigo|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.