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Medicineworld.org: Risks of Dementia drug treatment

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Risks of Dementia drug treatment




Side effects linked to several commonly-prescribed dementia drugs appears to be putting elderly Canadians at risk, says Queen's University Geriatrics professor Sudeep Gill.

Cholinesterase inhibitors (Aricept, Exelon and Reminyl) are often prescribed for people with Alzheimer's disease and related dementias because they increase the level of a chemical in the brain that seems to help memory. Eventhough such drugs are known to provoke slower heart rates and fainting episodes, the magnitude of these risks has not been clear until now.



Risks of Dementia drug treatment
Geriatrics professor Sudeep Gill leads new study investigating side effects of dementia drugs.

Photo by Jeff Drake

"This is very troubling, because the drugs are marketed as helping to preserve memory and improve function," says Dr. Gill, who is an Ontario Ministry of Health and Long-term Care Career Scientist, working at Providence Care's St. Mary's of the Lake Hospital in Kingston. "But for a subset of people, the effect may be the exact opposite."

In a large study using province-wide data, Dr. Gill and colleagues discovered that people who used cholinesterase inhibitors were hospitalized for fainting almost twice as often as people with dementia who did not receive these drugs. Experiencing a slowed heart-rate was 69 per cent more common amongst cholinesterase inhibitor users. In addition, people taking the dementia drugs had a 49 per cent increased chance of having permanent pacemakers implanted and an 18 per cent increased risk of hip fractures.

Unfortunately, Dr. Gill continues, this class of drugs is one of the few effective dementia therapys available today. Acknowledging that these drugs do have an important role in the management of dementia, he suggests that people who are already at a higher risk (for example, those who have had prior episodes of fainting or slowed heart rate) may want to ask their doctors to reassess the value of taking the drugs.

Slowing of the heart rate from cholinesterase inhibitors, if significant, may cause a person to faint and suffer fall-related injuries such as a broken hip - often debilitating and sometimes fatal for seniors. However, a number of physicians aren't aware of the correlation between these problems and the dementia drugs, Dr. Gill notes.

If the association with dementia drugs is not identified, people who faint appears to be prescribed a permanent pacemaker: an invasive procedure that can involve serious complications for seniors. Both the injuries incurred from falling and the risks from pacemaker implants are "downstream consequences" of not recognizing this drug-induced phenomenon.

"This study does not suggest that dementia patients shouldn't take these drugs," says Dr. Gill. "What's critical is that patients, caregivers and physicians be aware of the potential side effects, and weigh these risks carefully against the potential for beneficial effects".

The findings appear in the journal, Archives of Internal Medicine. Researchers from the Institute for Clinical Evaluative Sciences, the University of Toronto and Harvard University are also on the research team.


Posted by: JoAnn    Source




Did you know?
Side effects linked to several commonly-prescribed dementia drugs appears to be putting elderly Canadians at risk, says Queen's University Geriatrics professor Sudeep Gill. Cholinesterase inhibitors (Aricept, Exelon and Reminyl) are often prescribed for people with Alzheimer's disease and related dementias because they increase the level of a chemical in the brain that seems to help memory. Eventhough such drugs are known to provoke slower heart rates and fainting episodes, the magnitude of these risks has not been clear until now.

Medicineworld.org: Risks of Dementia drug treatment

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