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Medicineworld.org: New treatment regimen for ovarian cancer

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New treatment regimen for ovarian cancer




Newly reported results from a major clinical trial show that adding bevacizumab (Avastin) to standard frontline chemotherapy for women with advanced ovary cancer and then continuing one of the majortenance dose of the drug afterwards significantly extends progression-free survival. Women receiving the new therapy regimen saw no worsening of their disease for 14.1 months, in comparison to 10.3 months for women receiving standard treatment.

The international, multi-center, randomized, double-blind, placebo-controlled Phase III clinical trial was conducted by a network of scientists known as the Gynecologic Oncology Group (GOG) and sponsored by the U.S. National Cancer Institute. The trial results were presented at the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO).



New treatment regimen for ovarian cancer

The trial marked the first time a molecularly targeted agent has been part of a validated strategy for treating advanced ovary cancer. It was also the first time one of the majortenance dosing approach involving any treatment has been outlined for the disease. Additionally, ongoing analysis of the trial data may offer insights into genetically defined subgroups of patients who benefited more than others, pointing to the possibility of more personalized, even more effective therapy for ovary cancer in the future.

"Ovary cancer remains one of the most deadly cancers in women, so this clinical advance is especially welcome," says Robert A. Burger, M.D., lead investigator on the GOG trial and director of the Women's Cancer Center at Fox Chase Cancer Center. "Before this, we could treat ovary cancer patients only with surgery and chemotherapy involving relatively toxic agents. Now, we have a third type of more targeted treatment to offer these patients, potentially opening the way to even greater progress in years to come".

As per the American Cancer Society, approximately 22,000 new cases of ovary cancer will be diagnosed this year, and about 15,000 women will die from their disease. Ovary cancer is the eighth most common cancer among women, excluding non-melanoma skin cancers. It ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system.

The trial, dubbed GOG-0218, enrolled 1,873 previously untreated women with advanced disease from 336 sites in four countries (U.S., Canada, South Korea, and Japan). The women were randomly assigned to one of three therapy protocols: standard chemotherapy (carboplatin and paclitaxel) plus placebo, followed by placebo maintenance for an up to 10 additional months; standard chemotherapy plus bevacizumab followed by placebo maintenance; and standard chemotherapy plus bevacizumab followed by bevacizumab maintenance. The type and frequency of bevacizumab-associated side effects were similar to those seen in prior cancer studies involving the drug.

Bevacizumab, a humanized monoclonal antibody, is an angiogenesis inhibitor, meaning that the drug limits tumor growth by interfering with the formation of new blood vessels to supply the tumor with needed nutrients. It acts by inhibiting the function of a naturally occurring protein called vascular endothelial growth factor, or VEGF, which is overproduced in a number of cancers and stimulates new blood vessel formation.


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Newly reported results from a major clinical trial show that adding bevacizumab (Avastin) to standard frontline chemotherapy for women with advanced ovary cancer and then continuing one of the majortenance dose of the drug afterwards significantly extends progression-free survival. Women receiving the new therapy regimen saw no worsening of their disease for 14.1 months, in comparison to 10.3 months for women receiving standard treatment.

Medicineworld.org: New treatment regimen for ovarian cancer

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