MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

Medicineworld.org: How you eat may be just as important as how much you eat

Back to breast cancer blog Blogs list Cancer blog  


Subscribe To Breast Cancer Blog RSS Feed  RSS content feed What is RSS feed?

How you eat may be just as important as how much you eat




How you eat appears to be just as important as how much you eat, if mice studies are any clue.

Cancer scientists have long studied the role of diet on breast cancer risk, but results to date have been mixed. New findings published in Cancer Prevention Research, a journal of the American Association for Cancer Research, suggest the method by which calories are restricted appears to be more important for cancer protection than the actual overall degree of calorie restriction.



How you eat may be just as important as how much you eat

"Understanding how calorie restriction provides protection against the development of mammary tumors should help us identify pathways that could be targeted for chemoprevention studies," said Margot P. Cleary, Ph.D., professor at the Hormel Institute, University of Minnesota. "Further identification of serum factors that are involved in tumor development would possibly provide a way to identify at risk individuals and target interventions to these people".

Prior studies have shown that intermittent calorie restriction provided greater protection from mammary tumor development than did the same overall degree of restriction, which was implemented in a chronic fashion. The scientists compared changes of a growth factor (IGF-1) in relationship to these two calorie restriction methods chronic and intermittent and tumor development beginning in 10-week old female mice at risk to develop mammary tumors. Their hope was to explain why intermittent restriction is more effective.

The overall degree of restriction was 25 percent reduction in comparison to control mice. Mammary tumor incidence was 71 percent in the control mice who ate the amount of food they wanted, 35 percent among those who were chronically restricted and only nine percent in those who intermittently restricted calories.

The scientists were initially surprised by these findings for several reasons. First, the prevailing wisdom is that the degree of protection from calorie restriction is proportional to the degree of mammary tumor prevention. Second, they originally thought that intermittent calorie restriction might enhance tumor growth due to growth factors being secreted in response to re-feeding, Cleary said.

In an accompanying editorial also published in Cancer Prevention Research, Michael Pollak, M.D., stated that some major challenges of pharmacologic approaches to cancer prevention and/or therapy include defining the underlying causes and determining the relevance of these caloric restriction methods. Pollak is professor of oncology at McGill University and director of the Cancer Prevention Center at the Jewish General Hospital, both in Montreal.

This study "contributes to accumulating evidence that caloric restriction acts by altering hormone levels rather than by directly starving cancers of energy. In particular, lower levels of insulin are linked to reduced food intake, and this appears to be protective," said Pollak, who is also an editorial board member for Cancer Prevention Research
In the editorial Pollak wrote: "there is reason for concern that the 'obesity epidemic' may lead to an increased prevalence of a hormonal profile linked to elevated cancer risk and/or an adverse cancer prognosis. Therefore, in addition to its well-known general health benefits, maintaining an ideal body weight is also important in the specific contexts of cancer prevention and improving the prognosis of cancer patients".

Based on varied findings from clinical trials, Pollak suggested that lifestyle and pharmacologic methods to reduce IGF-1 and insulin deserve ongoing investigations. Cleary agreed, stating that these results may provide interest to more aggressively pursue cancer prevention studies correlation to calorie restriction.

"Humans frequently regain lost weight discouraging the application of calorie restriction protocols for disease prevention," she said. "We hope these studies will identify biomarkers and/or pathways that could be used in human studies to determine agents that would mimic calorie restriction".


Posted by: Janet    Source




Did you know?
How you eat appears to be just as important as how much you eat, if mice studies are any clue. Cancer scientists have long studied the role of diet on breast cancer risk, but results to date have been mixed. New findings published in Cancer Prevention Research, a journal of the American Association for Cancer Research, suggest the method by which calories are restricted appears to be more important for cancer protection than the actual overall degree of calorie restriction.

Medicineworld.org: How you eat may be just as important as how much you eat

BREAST CANCER MAIN| Home| Breast cancer news| Common terms| Breast cancer treatment| Breast cancer treatment by stage| Mammogram and breast cancer screening| Surgical treatment of breast cancer| Chemotherapy of breast cancer| Chemo drugs used in breast cancer| Doxorubicin| Cyclophosphamide| Methotrexate| Hormonal therapy of breast cancer| Radiation therapy of breast cancer| Monoclonal therapy| High dose chemotherapy for breast cancer| Recurrent breast cancer| Bisphosphonates and breast cancer| Pregnancy and breast cancer| Risk factors for breast cancer| Risk details| My risk| Comprehensive breast cancer information| Breast cancer statistics| African Americans and breast cancer| Ashkenazi and breast cancer| Asians| Hispanic| Men| Native Americans| Older women and breast cancer| Younger women| Pregnant women and breast cancer| BRCA|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.