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Medicineworld.org: Genetic variation linked to lupus

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Genetic variation linked to lupus




Genes reside along long chains of DNA called chromosomes. UCLA scientists have observed that a variation in a gene on the sex chromosome X may enhance an immune response that leads to lupus in men.

Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women. Interestingly, scientists observed that eventhough the variation occurred in a gene on the X, or female, chromosome, its influence was stronger in men than in women. Humans hold two sex chromosomes men have an X and Y, while women have two Xs. Prior studies have shown that genetic variations on the X chromosome contribute to the development of lupus.



Genetic variation linked to lupus

In this study, scientists observed that certain common variations of DNA sequences within a specific X-linked gene triggered a stronger response in the immune system, increasing the risk of developing lupus, particularly in men.

This study was part of an international effort to study the genetics of lupus in broader ethnic groups. Scientists genotyped 9,274 Eastern Asians individuals, including those with lupus and healthy controls. The stronger genetic effects were seen in men, compared with women, and particularly in Chinese and Japanese men. Further study will look at other ethnicities.

Scientists say the finding will lead to greater understanding of the development of lupus and to further exploration of the sex-specific genetic contributions of the disease, which could result in more targeted therapies.


Posted by: Mark    Source




Did you know?
Genes reside along long chains of DNA called chromosomes. UCLA scientists have observed that a variation in a gene on the sex chromosome X may enhance an immune response that leads to lupus in men. Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women. Interestingly, scientists observed that eventhough the variation occurred in a gene on the X, or female, chromosome, its influence was stronger in men than in women. Humans hold two sex chromosomes men have an X and Y, while women have two Xs. Prior studies have shown that genetic variations on the X chromosome contribute to the development of lupus.

Medicineworld.org: Genetic variation linked to lupus

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