New anti-viral drug for hepatitis C

---

---

---

Adding a direct acting anti-viral drug to the standard therapy regimen for hepatitis C significantly increases the cure rate in the most difficult to treat patients, as per a research report published Monday in the online edition of the journal The Lancet
The research team, led by Paul Kwo, M.D., of Indiana University School of Medicine, reported that adding the drug nearly doubled the therapy's effectiveness when given for 48 weeks in one therapy arm of the study.

An estimated 3.2 million Americans and 170 million people worldwide are infected with the hepatitis C virus, but a number of do not know it. In the United States, 70 percent of affected individuals are infected with genotype 1 hepatitis C, the most difficult to treat. Eventhough there appears to be no symptoms for years, long-term infection can cause cirrhosis and the disease is a leading cause of liver cancer and liver transplantation. Hepatitis C infections occur mainly through transmission of infected blood, such as via injection drug use, and there is no vaccine.

Currently fewer than half of patients with genotype 1 hepatitis C are treated effectively by the standard combination of two drugs, peginterferon alfa-2b plus ribavirin, which is typically given for 48 weeks. The therapy can be difficult for some patients due to anemia and other side effects.

Adding the drug boceprevir increased the cure rate to as high as 75 percent in those who received 48 weeks of the three-drug combination treatment, in comparison to 38 percent of those in the control group, who received the standard two-drug therapy for 48 weeks, said Dr. Kwo, associate professor of medicine at the IU School of Medicine. The two-year phase 2 trial was conducted at 67 sites with 520 patients in the U.S., Canada and Europe.

In the boceprevir study, known as the SPRINT-1 trial, scientists tested several different options to evaluate the effectiveness of the combination treatment:

• To test whether the addition of boceprevir could make it possible to shorten therapy times, some patients were randomly selected to receive the three-drug combination for 28 weeks, some for 48 weeks.
  
• Scientists also investigated whether a 4 week lead-in with the standard two-drug combination previous to the addition of boceprevir to the therapy regime could improve sustained virologic response rates. The goal was to see if allowing the interferon and ribavirin to reach steady state levels -- which would activate the immune system and reduce virus levels -- before adding boceprevir would improve the response rates as well as reduce the virus' ability to develop resistance to boceprevir, said Kwo.
  
• In another arm of the trial, scientists tested whether a lower dose of ribavirin could reduce the anemia side effects while still treating the virus effectively.
  

"Both 28- and 48-week boceprevir regimens significantly increased sustained virologic response rates which is the best definition of a cure we have in comparison to the 48 week control," said Dr. Kwo. "The 48-week therapy arm with 4 weeks of peg interferon lead-in and 44 weeks of peg interferon, ribavirin, and boceprevir led to the largest improvement over the control group ever reported. That's very impressive".

Boceprevir, a product of Merck & Co., is an HCV protease inhibitor a compound designed to block a function key to viral reproduction in the cell. Boceprevir directly targets the hepatitis C virus, Kwo noted, while peginterferon and ribavirin are less specific, acting more generally to stimulate the body's virus-fighting immune system.

The best results were reported for the 103 patients who were treated for four weeks with the standard two drug regiment, followed by 44 weeks of the three-drug regimen including boceprevir: 75 percent of these patients tested negative for evidence of the virus six months after the end of therapy. Results for the other therapy arms were:

• 67 percent of those who received the three drug regimen for 48 weeks with no lead-in therapy tested negative for the virus (103 patients).
  
• 56 percent of those who received the two-drug lead-in for four weeks, followed by 24 weeks of the three drug therapy tested negative for the virus (103 patients).
  
• 54 percent of those who received the three-drug therapy for 28 weeks with no lead-in tested negative for the virus (107 patients).
  
• 38 percent of the control group, who received the standard two-drug therapy for 48 weeks tested negative for the virus (104 patients).
  

Patients receiving the low-dose of ribavirin did not fare as well just 36 percent were virus-free after 48 weeks of therapy.

"Based on this phase 2 study, it appears that if this drug receives final approval approximately two-thirds of patients will be able to be treated successfully with 28 weeks of therapy and one-third will need 48 weeks of therapy, though this will require confirmation from the phase 3 trials, from which preliminary results were recently released," said Dr. Kwo.


Posted by: Mark    Source