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Medicineworld.org: Metabolic syndrome, liver disease and obese teenaged boy

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Metabolic syndrome, liver disease and obese teenaged boy




Scientists studying a large sample of adolescent American boys have found an association between metabolic syndrome, which is a complication of obesity, and elevated liver enzymes that mark potentially serious liver disease.

The link between metabolic syndrome and the suspected liver disease did not appear in adolescent girls, said study leader Rose C. Graham, M.D., a pediatric gastroenterologist at The Children's Hospital of Philadelphia. There were ethnic differences among the boys as well, she added, between Hispanic and non-Hispanic males.

The study appears in the October 2009 print edition of the Journal of Pediatric Gastroenterology and Nutrition



Metabolic syndrome,  liver disease and obese teenaged boy

Metabolic syndrome is of concern as a risk factor for cardiovascular disease and type 2 diabetes, and is estimated to occur in 22 percent of U.S. adults and 4 percent of U.S. adolescents. It is defined by insulin resistance, increased waist circumference, high blood pressure, and abnormal measures of high density lipoprotein ("good cholesterol") and triglycerides in the blood. The criteria are similar for pediatric metabolic syndrome, eventhough there is some dispute over details of the definition.

In adults, scientists have shown an association between metabolic syndrome and a group of diseases called nonalcoholic fatty liver disease (NAFLD), which at its most severe, may progress to irreversible liver damage. The purpose of the current study was to investigate to what extent metabolic syndrome in adolescents was linked to elevated levels of the liver enzyme alanine aminotransferase (ALT), a marker of NAFLD.

Graham and his colleagues analyzed a nationally representative sample of 1,323 U.S. adolescents, aged 12 to 19, from the National Health and Nutrition Examination Survey. They found a strong association between metabolic syndrome and elevated ALT levels in adolescent males, but not in adolescent females.

While looking more carefully at this association in boys, they observed that among Hispanic males, this association largely coincided with being obese, as measured by body mass index. The scientists expected to find this correlation, because for all ethnicities, obesity was already known to be a risk factor for both metabolic syndrome and NAFLD. However, they also observed that among non-Hispanic adolescent boys, metabolic syndrome and high ALT levels were linked to each other, independent of obesity. "Something else seems to be going on, in addition to the effects of obesity," said Graham. "Some unknown factors appears to be at work here".

The finding may have implications for therapy, she added. Currently, the only known therapy for NAFLD is weight loss. "If some adolescents with metabolic syndrome appears to be susceptible to this liver disease regardless of whether or not they are obese, there appears to be other therapys yet to be discovered".

NAFLD is increasingly being recognized among overweight teenagers. "Our findings suggest that NAFLD in adolescents merits closer attention, and its therapy may require more than just weight loss," said Graham.


Posted by: JoAnn    Source




Did you know?
Scientists studying a large sample of adolescent American boys have found an association between metabolic syndrome, which is a complication of obesity, and elevated liver enzymes that mark potentially serious liver disease. The link between metabolic syndrome and the suspected liver disease did not appear in adolescent girls, said study leader Rose C. Graham, M.D., a pediatric gastroenterologist at The Children's Hospital of Philadelphia. There were ethnic differences among the boys as well, she added, between Hispanic and non-Hispanic males.

Medicineworld.org: Metabolic syndrome, liver disease and obese teenaged boy

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